Das Verhalten der cellul�ren Potentiale der Herzmuskulatur bei verschiedenen experimentellen ?Insuffizienzformen?

Luellmann, H

doi:10.1007/bf00244538

Cited by 21 publications

(5 citation statements)

References 19 publications

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“…These findings are in agreement with those in the frog ventricle (13,14), in rabbit auricle (15,16), in turtle ventricular strips (17), in rat auricle and dog and cat ventricular muscle (18). The iodoacetate-induced reduction in duration of the action potential in the presence of 5% CO 2 in O 2 was slow, indicating that certain aerobic pathways for oxidation of metabolites such as lactate and pyruvate are unaffected by iodoacetate.…”

Section: Discussionsupporting

confidence: 86%

Influence of Glucose on the Transmembrane Action Potential of Guinea-Pig Papillary Muscle

Prasad

MacLeod

1969

Circulation Research

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In a previous report, we have proposed that anaerobic glycolysis alone can maintain an action potential of normal duration in guinea-pig papillary muscle. This proposal followed from the observation that 50 m\i glucose, several sympathomimetic amines, and aminophylline all caused the duration of the action potential of muscles, which had been reduced by incubation in a medium containing 5 mM glucose, to return toward control values. This occurred in the presence or absence of oxygen. It was further proposed that the ATP resulting from anaerobic glycolysis was in some way preferentially utilized in the membrane by a process controlling repolarization and therefore the duration of the action potential. The present experiments were undertaken to determine what metabolic pathways were necessary for the glucose effect mentioned above, by the use of the metabolic inhibitors sodium cyanide, iodoacetic acid, and 2,4-dinitrophenol. Secondly, the effects of ouabain and calcium, which are known to modulate the utilization of ATP, on the glucose effect were studied. It was concluded that an intact glycolytic pathway is necessary for the effect of glucose on the electrical activity of papillary muscle and that the effect can be increased or decreased by low or high doses of ouabain, respectively. The actions of ouabain are thought to be due to a stimulation and depression of a membrane ATP-ase. ADDITIONAL KEY WORDS duration of action potential glycolysis ATP anoxia contractile force repolarizationFrom the

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Section: Discussionsupporting

confidence: 86%

Influence of Glucose on the Transmembrane Action Potential of Guinea-Pig Papillary Muscle

Prasad

MacLeod

1969

Circulation Research

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“…Several studies have been carried out on the effects of anoxia, substrate depletion, or metabolic inhibitors on cardiac muscle (Trautwein and Dudel, 1956;Webb and Hollander, 1956;Kleinfield et al, 1961Kleinfield et al, , 1962de Mello, 1959;Boulpaep, 1959;Lullmann, 1959). In both atrial and ventricular muscle the earliest effects were depression in force of contraction and reduc-tion in action potential duration.…”

Section: Introductionmentioning

confidence: 99%

Influence of Glucose on the Transmembrane Action Potential of Anoxic Papillary Muscle

MacLeod

Daniel

1965

The Journal of General Physiology

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The response of the cat papillary muscle to anoxia has been found to alter depending on the glucose concentration in the medium. At a glucose concentration of 5 mM anoxia caused a marked reduction in force of contraction and action potential duration within 20 minutes. At a glucose concentration of 50 mM anoxia induced similar changes in the force of contraction but little or no change in action potential duration. Elevation of glucose concentration during an anoxic interval reversed the anoxia-induced changes in action potential but had little effect on force of contraction. This effect of glucose could be partially duplicated by xylose and 2-deoxyglucose and in addition, 2-deoxyglucose has been found to prevent the effect of subsequently added glucose. These sugars appear to be transported by a system responsible for glucose transport but are not metabolized to any extent. It would appear therefore that transport of glucose is in some way related to transport of potassium as increased potassium permeability is thought by many to be responsible for anoxia-induced changes in action potential duration.

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“…Although attempts have been made to relate the antiarrhythmic effect of quinidine to its impairment of the consumption of oxygen and glucose (Hess & Haugaard, 1958; for review see Conn & Luchi, 1964) it seems much more likely that the influence of this drug on ionic movements through the cell membrane is the actual cause of its antifibrillatory action. Electrophysiological studies by Lullmann (1959) have demonstrated the retarded influx of Na+ ions during depolarization on exposure of guinea-pig atria to quinine. In tracer experiments with '2K, quinidine has been shown to reduce the K+ efflux considerably (Holland, 1957;Holland, Klein & Briggs, 1959;Conn & Wood, 1960;Klein, Holland & Tinsley, 1960).…”

Section: Discussionmentioning

confidence: 99%

“…Electrophysiological studies by Lullmann (1959) have demonstrated the retarded influx of Na+ ions during depolarization on exposure of guinea-pig atria to quinine. In tracer experiments with '2K, quinidine has been shown to reduce the K+ efflux considerably (Holland, 1957;Holland, Klein & Briggs, 1959;Conn & Wood, 1960;Klein, Holland & Tinsley, 1960).…”

Section: Discussionmentioning

confidence: 99%

“…For quinidine, this decrease in ionic permeability of the membrane has been demonstrated by means of isotope experiments with 42K (Holland, 1957;Holland, Klein & Briggs, 1959;Klein, Holland & Tinsley, 1960). Electrophysiological experiments have shown that quinine inhibits sodium influx during excitation (Lullmann, 1959). Although most antifibrillatory agents are believed to act by the same mechanism, the influence of such drugs on ion fluxes has usually not been studied quantitatively, probably because the short-lived isotopes '4K and 24Na, necessary for such studies, are difficult to handle.…”

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confidence: 99%

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Decrease in ionic permeability of the cell membrane in guinea‐pig atrial tissue by treatment with antifibrillatory agents and hexobarbitone, determined by means of ⁸⁶Rb

Zwieten¹

1969

British J Pharmacology

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1. The influence of antifibrillatory agents on the release of previously accumulated MRb+ ions was studied in guinea-pig isolated left auricles, incubated in a K+-free Tyrode solution that contained an equivalent concentration (2.7 mM) of Rb+. The auricles were stimulated electrically at a frequency of 100/min and showed entirely " normal " mechanical behaviour in the incubation medium. 2. Quinidine, tetracaine, hexobarbitone-Na and propranolol caused a dosedependent negative inotropic effect. The frequency of beating (100/min) was usually not affected by these drugs. 3. The reduction in contractile force was accompanied by a dose-dependent inhibition of wRb release. The concentration-response curves for both the mechanical effect and the influence on MRb release almost coincided for quinidine, although these curves diverged for the other drugs studied. 4. It is suggested that all the four different antifibrillatory drugs cause a general reduction of the membrane permeability to inorganic ions. The mechanism of this membrane stabilization remains unknown.

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Das Verhalten der cellul�ren Potentiale der Herzmuskulatur bei verschiedenen experimentellen ?Insuffizienzformen?

Cited by 21 publications

References 19 publications

Influence of Glucose on the Transmembrane Action Potential of Guinea-Pig Papillary Muscle

Influence of Glucose on the Transmembrane Action Potential of Guinea-Pig Papillary Muscle

Influence of Glucose on the Transmembrane Action Potential of Anoxic Papillary Muscle

Decrease in ionic permeability of the cell membrane in guinea‐pig atrial tissue by treatment with antifibrillatory agents and hexobarbitone, determined by means of ⁸⁶Rb

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Das Verhalten der cellul�ren Potentiale der Herzmuskulatur bei verschiedenen experimentellen ?Insuffizienzformen?

Cited by 21 publications

References 19 publications

Influence of Glucose on the Transmembrane Action Potential of Guinea-Pig Papillary Muscle

Influence of Glucose on the Transmembrane Action Potential of Guinea-Pig Papillary Muscle

Influence of Glucose on the Transmembrane Action Potential of Anoxic Papillary Muscle

Decrease in ionic permeability of the cell membrane in guinea‐pig atrial tissue by treatment with antifibrillatory agents and hexobarbitone, determined by means of 86Rb

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Decrease in ionic permeability of the cell membrane in guinea‐pig atrial tissue by treatment with antifibrillatory agents and hexobarbitone, determined by means of ⁸⁶Rb