Das so genannte spontane Liquorunterdrucksyndrom

Straube, Andreas; Neudert, Christine; Glas, Martin; Brüning, R.; Padovan, Claudio S.

doi:10.1007/s00115-004-1752-1

Cited by 13 publications

(5 citation statements)

References 35 publications

(18 reference statements)

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“…Caffeine increases cerebral vasoconstriction by blocking adenosine receptors and leads to augmented CSF production by stimulating sodium-potassium pumps [59]. Mathew and Wilson [60] demonstrated a reduction in cerebral blood flow after the intravenous administration of caffeine benzoate for the treatment of PDPH.…”

Section: Treatmentmentioning

confidence: 99%

Postdural puncture headache

Kwak

2017

Korean J Anesthesiol

138

128

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Postdural puncture headache (PDPH) is a common complication after inadvertent dural puncture. Risks factors include female sex, young age, pregnancy, vaginal delivery, low body mass index, and being a non-smoker. Needle size, design, and the technique used also affect the risk. Because PDPH can be incapacitating, prompt diagnosis and treatment are mandatory. A diagnostic hallmark of PDPH is a postural headache that worsens with sitting or standing, and improves with lying down. Conservative therapies such as bed rest, hydration, and caffeine are commonly used as prophylaxis and treatment for this condition; however, no substantial evidence supports routine bed rest and aggressive hydration. An epidural blood patch is the most effective treatment option for patients with unsuccessful conservative management. Various other prophylactic and treatment interventions have been suggested. However, due to a lack of conclusive evidence supporting their use, the potential benefits of such interventions should be weighed carefully against the risks. This article reviews the current literature on the diagnosis, risk factors, pathophysiology, prevention, and treatment of PDPH.

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Section: Treatmentmentioning

confidence: 99%

Postdural puncture headache

Kwak

2017

Korean J Anesthesiol

138

128

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“…By blocking adenosine receptors, caffeine increases cerebral arterial vasoconstriction, and leads to a decrease in cerebral blood inflow and brain blood volume. On the other hand, caffeine leads to augmentation of cerebrospinal fluid production by stimulating sodium-potassium pumps (35, 40). It seems that caffeine administration is a noninvasive and safe option that may prevent the use of invasive methods such as epidural blood patching, or epidural injection of NaCl 0.9% (35, 41).…”

Section: Resultsmentioning

confidence: 99%

The Role of Caffeine in Pain Management: A Brief Literature Review

Baratloo

Rouhipour²,

Forouzanfar

et al. 2016

Anesth Pain Med

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Context:Caffeine is the most commonly used psychoactive legal drug in the world. Caffeine’s role in controlling pain has received less attention in the past, yet is being increasingly considered. This article briefly reviewed the literature to clarify the role of caffeine as a drug for pain control and attract investigators to this topic.Evidence Acquisition:The data on Caffeine as an adjuvant therapy or as a main component for pain modulation has been narratively reviewed.Results:Caffeine plays an important role in pain modulation through their action on adenosine receptors which are involved in nociception. The use of caffeine as adjuvant treatment was well-established in the literature and caffeine is currently available in some over the counter medications. Studies showed controversial results about the interaction between caffeine and morphine for pain relief in patients with terminal stage cancer. As a main component for pain modulation, Caffeine can be used for hypnic headache and postdural puncture headache.Conclusions:Caffeine has a potential role for pain modulation. Current evidence on caffeine use for migraine and terminal stage cancer is not well-established. Future studies should address the use of caffeine alone for different types of pain with dose escalation and standardization of outcome measurement.

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“…These treatments seek to reduce cerebrospinal fluid loss through the dural holes and replenish it through increased fluid ingestion [12]. Although these tech niques are easy to apply and do not have any sig nificant negative side effects, there are insufficient data to recommend their usage in the prevention of PDPH [13,14]. The authors of a 2016 Cochrane review found insufficient proof that routine bed rest following a dural puncture prevents PDPH [12].…”

Section: Discussionmentioning

confidence: 99%

Intranasal sphenopalatine ganglion block by lignocaine spray for postdural puncture headache following spinal anesthesia: a randomized clinical trial

Smita,

Dubey,

Singh

2023

ait

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Background:In a randomized clinical study, we investigated the effectiveness of nasal lignocaine spray and swabs in treating postdural puncture headache (PDPH) after spinal anesthesia.Methods: Group S patients received two puffs of lignocaine 10% spray in both nostrils followed by cotton soaked in normal saline, and group B patients received two puffs of saline spray in both nostrils followed by a cotton swab soaked in lignocaine 2%. Patients were assessed before the procedure and 30 minutes, 60 minutes, 2 h, 24 h, 48 h, and 72 h after the procedure for pain relief with the help of a visual analogue scale (VAS). Hemodynamic parameters and adverse effects were also recorded. Normally distributed continuous variables were expressed as mean (95% confidence interval) whereas non-normally distributed variables were expressed as median (IQR). Repeated measures analysis of variance was used to compare the VAS score at different time points between test and control groups. The difference in means between the two groups was compared using the independent sample t-test. The paired t-test was used to compare the changes in clinical and laboratory variables.Results: At each time point, the mean VAS score for pain was substantially different between the two groups. Moreover, until the second hour, the VAS score was significantly lower in group S than in group B. No significant intervention-related adverse effect was observed in either group. Conclusions:Without any noticeable side effects, lignocaine 10% spray is more successful in treating PDPH after spinal anesthesia, particularly in the first two hours.

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Das so genannte spontane Liquorunterdrucksyndrom

Cited by 13 publications

References 35 publications

Postdural puncture headache

Postdural puncture headache

The Role of Caffeine in Pain Management: A Brief Literature Review

Intranasal sphenopalatine ganglion block by lignocaine spray for postdural puncture headache following spinal anesthesia: a randomized clinical trial

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