Das Rauwolfia-Alkaloid Reserpin als wirksame Strahlenschutzsubstanz

Melching, H.; Langendorff, M.

doi:10.1007/bf00629453

Cited by 18 publications

(2 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Reserpine is effective when given 12-24 hr. before irradiation (153), possibly by release of serotonin and catecholamines (154). Two other hypotensive agents, l-hydrazinophthalazine and guanethidine (155) have some protective effect.…”

mentioning

confidence: 99%

Radiation-Protective Agents in Mammals

Foye¹

1969

Journal of Pharmaceutical Sciences

View full text Add to dashboard Cite

mentioning

confidence: 99%

Radiation-Protective Agents in Mammals

Foye¹

1969

Journal of Pharmaceutical Sciences

View full text Add to dashboard Cite

“…Nach Bacq [3], Melching und Langendorff [32] ist die Voraussetzung für eine Schutzwirkung die, dass sich der betreffende Stoff in genügend hoher Menge während der Bestrahlung im Körper befindet. Alle bis heute untersuchten Substanzen haben keine Schutzwirkung, wenn sie nach der Bestrahlung gegeben werden.…”

unclassified

Experimentelle Untersuchungen über die Strahlenschutzwirkung von Trihydroxyaethyl-Rutosid (Venoruton P<sub>4</sub>)

Zukerman¹

1967

Dermatology

View full text Add to dashboard Cite

Radiosensitizers and Radioprotective Agents

Bump¹,

Hoffman²,

Foye

2003

Burger's Medicinal Chemistry and Drug Discovery

View full text Add to dashboard Cite

Various approaches have been developed for diminishing the effects of radiation on normal tissues or enhancing tumor cell killing by ionizing radiation. An important potential use for these agents is to modify the outcome of radiation therapy. Potential radioprotectors or radiosensitizers are organized in this review according to mechanism of action. Most of the agents studied are believed to act by reacting with DNA radicals that are produced within milliseconds of exposure to ionizing radiation. According to this mechanism, protectors restore a single electron to electron‐deficient radicals, preventing degradation of the structure of DNA, whereas sensitizers, such as molecular oxygen or nitroimidazoles, form adducts with these radicals, resulting in damage fixation. WR2721 (Ethyol) is the best‐characterized chemical radioprotector. Preferential activation of WR2721 in certain normal tissues by removal of a phosphate group provides a rationale for selective protection of these tissues. Cytokines and biological modifiers represent an important emerging class of radioprotectors that may be particularly useful in modifying bone marrow injury. Nitroimidazoles have been the most widely studied chemical radiosensitizers. Although clinical results with nitroimidazoles have not been impressive, the potential for this approach has not been fully explored, given that the doses that can be administered have been limited by drug toxicity and supplemental strategies, such as concurrent depletion of endogenous protectors, have not been explored in the clinic. Modifiers of tumor oxygenation represent an important class of radiosensitizers that are currently generating considerable clinical interest. RSR13, a modifier of the oxygen affinity of hemoglobin, is highlighted as an example of the process of drug development for this type of agent.

show abstract

Das Rauwolfia-Alkaloid Reserpin als wirksame Strahlenschutzsubstanz

Cited by 18 publications

References 1 publication

Radiation-Protective Agents in Mammals

Radiation-Protective Agents in Mammals

Experimentelle Untersuchungen über die Strahlenschutzwirkung von Trihydroxyaethyl-Rutosid (Venoruton P<sub>4</sub>)

Radiosensitizers and Radioprotective Agents

Contact Info

Product

Resources

About