“…In addition, prompt treatment of pain, widely-regarded as the fifth vital sign, is beneficial for reducing suffering, readmissions and emergency department visits after hospital discharge [ 36 ]. Although many studies have reported on how to eliminate chronic post-traumatic lymphedema [ [37] , [38] , [39] ], the effect of lymphatic drainage on acute post-traumatic hematoma and pain is not clear. With the treatment of anti-PDPN neutralizing antibody, we determined that improving lymphatic drainage reduces acute post-traumatic edema and pain, suggesting that defects in lymphatic drainage plays a key role in the early complications of traumatic fracture.…”