Das Patient-Blood-Management-Konzept

Meybohm, Patrick; Schmitz‐Rixen, Thomas; Steinbicker, Andrea U.; Schwenk, W.; Zacharowski, Kai

doi:10.1007/s00104-017-0506-0

Cited by 20 publications

(5 citation statements)

References 16 publications

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“…Victims of blunt trauma have a significantly higher risk of post-traumatic infection than patients with penetrating trauma (24). Our results do not support the currently discussed idea, that blood transfusions facilitate the development of infections (47). In contrast, it could be concluded that the longer time of endotracheal intubation (ETI) and ICU stay of inf+PT are logically related to the complications of the infection.…”

Section: Post-traumatic Infections Are Mainly Caused By Gram-negative Enterobacteriaceaecontrasting

confidence: 99%

Influence of Antibiotic Management on Microbial Selection and Infectious Complications After Trauma

et al. 2021

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Background: The inflammatory response and post-traumatic complications like infections play an important role in the pathophysiology of severe injuries. This study examines the microbiological aspects in anti-infective treatment of trauma patients and their inflammatory response in post-traumatic infections complications.Patients and Methods: A retrospective analysis of prospectively collected data in trauma patients (ISS ≥ 16) over a 1-year period (01/2018 to 12/2018) is provided. Patient population was stratified into severely injured patients without post-traumatic infection (inf-PT), and severely injured patients who developed an infection (inf+PT).Results: Of 114 trauma patients, 45 suffered from post-traumatic infection during the first 10 days of hospitalization. Severely injured patients with concomitant traumatic brain injury (PT+TBI) showed the highest rate of post-traumatic infection. Pro-inflammatory reaction was tracked by levels of Interleukin (IL-)6 (day 3: inf+T 190.8 ± 359.4 pg/dL > inf-PT 56.2 ± 57.7 pg/mL (mean ± SD); p = 0.008) and C-Reactive-Protein (CRP, day 3: inf+PT 15.3 mg/dL > inf-PT 6.7 mg/dL, p = 0.001) which were significantly higher in trauma patients who develop an infectious complication and showed a significant positive correlation with the occurrence of infection. The leading entity of infection was pneumonia followed by infections of the urinary tract mainly caused by gram-negative Enterobacteriaceae. 67.5% of all trauma patients received single-shot antibiosis during initial care in trauma bay. The development of secondary colonization was not relevant positively correlated with single-shot antibiosis (r = 0.013, p = 0.895) and prophylactically calculated antibiotic administration (r = 0.066, p = 0.500).Conclusion: Severely injured trauma patients have an increased risk for development of infectious complications, which mainly is pneumonia followed by infection of the urinary tract mainly caused by gram-negative Enterobacteriaceae. Based on the data in this study, the one-time antibiotic and prophylactic calculated use of antibiotics, like Cephalosporins must be critically discussed in terms of their role in the development of post-traumatic infections and microbial selection.

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Section: Post-traumatic Infections Are Mainly Caused By Gram-negative Enterobacteriaceaecontrasting

confidence: 99%

Influence of Antibiotic Management on Microbial Selection and Infectious Complications After Trauma

et al. 2021

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“…With the aging "baby boomer" generation, the demand for blood will likely increase in the next 10-15 years, when this population group shifts from being potential donors to those requiring most of the transfusions [3,4]. However, in the past ten years, transfusion demand decreased in many European countries, too, mostly due to an active reduction within patient blood management programs [5] or improved treatment options with a smaller need for blood. It is unclear whether this trend will continue, as some hospitals already implemented very restrictive transfusion triggers [4].…”

Section: Introductionmentioning

confidence: 99%

“Blood for Blood”? Personal Motives and Deterrents for Blood Donation in the German Population

Greffin

Schmidt

Schönborn

et al. 2021

IJERPH

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It is crucial to provide updated knowledge about blood (non-)donors, as it is necessary to design targeted interventions with the aim of retaining blood donors and thus contributing to a functioning health system. This study investigates the prevalence and socio-demographic patterning of lifetime blood donation, assessing blood donation intention within the next 12 months and exploring personal motives and deterrents of blood donation qualitatively in the German population. A face-to-face cross-sectional survey with 2531 respondents was conducted, representative of the German population in terms of age, gender, and residency. Closed as well as open questions were asked. Qualitative content analysis was used for coding the qualitative material. Basic descriptive statistics were conducted to address our research questions. More than one-third of the participants reported that they have donated blood at least once in their lifetime. Motives and deterrents were assigned to 10 domains with 50 main categories and 65 sub-categories. The most frequently stated motives for blood donation were “altruism”, “social responsibility”, and “charity”, whereas the most frequently stated deterrents were “health status”, “age”, and “lack of time”. This study provides information to tailor recruitment and reactivation strategies to address donors at different career steps—from non-donor to loyal donor.

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“…Although the PBM was primarily introduced in the area of adult care, its individual measures may also have had an impact on pediatrics. The treatment of iron deficiency anemia with iron preparations or the use of erythropoietin; reduction of the number and volume of blood samples; and adherence to physiological conditions of hemostasis (pH, calcium concentration and temperature) can be used, as well as the use of bedside coagulation diagnostics and targeted therapy in children [2, 13-15, 16-24].…”

Section: Discussionmentioning

confidence: 99%

Changes in Transfusion Practice in Children and Adolescents over Time

Piekarski

Steinbicker

Zacharowski

et al. 2020

Transfus Med Hemother

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Introduction: In recent years, resource-saving handling of allogeneic blood products and a reduction of transfusion rates in adults has been observed. However, comparable published national data for transfusion practices in pediatric patients are currently not available. In this study, the transfusion rates for children and adolescents were analyzed based on data from the Federal Statistical Office of Germany during the past 2 decades. Methods: Data were queried via the database of the Federal Statistical Office (Destasis). The period covered was from 2005 to 2018, and those in the sample group were children and adolescents aged 0-17 years receiving inpatient care. Operation and procedure codes (OPS) for transfusions, procedures, or interventions with increased transfusion risk were queried and evaluated in detail. Results: In Germany, 0.9% of the children and adolescents treated in hospital received a transfusion in 2018. A reduction in transfusion rates from 1.02% (2005) to 0.9% (2018) was observed for the total collective of children and adolescents receiving inpatient care. Increases in transfusion rates were recorded for 1-to 4-(1.41-1.45%) and 5-to 10-year-olds (1.24-1.33%). Children under 1 year of age were most frequently transfused (in 2018, 40.2% of the children were cared for in hospital). Transfusion-associated procedures such as chemotherapy or machine ventilation and respiratory support for new-borns and infants are on the rise. Conclusion: Transfusion rates are declining in children and adolescents, but the reasons for increases in transfusion rates in other groups are unclear. Prospective studies to evaluate transfusion rates and triggers in children are urgently needed.

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Das Patient-Blood-Management-Konzept

Cited by 20 publications

References 16 publications

Influence of Antibiotic Management on Microbial Selection and Infectious Complications After Trauma

Influence of Antibiotic Management on Microbial Selection and Infectious Complications After Trauma

“Blood for Blood”? Personal Motives and Deterrents for Blood Donation in the German Population

Changes in Transfusion Practice in Children and Adolescents over Time

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