Das Marjolin-Ulkus

BACKGROUND:The concept of immunocompromised districts of skin has been developed by Ruocco and helps to explain certain aspects of the macromorphology of skin diseases. This concept unites the isomorphic response of Koebner and the isotopic response of Wolf.CASE REPORTS:We present different cutaneous conditions which can lead to immunocompromised districts of skin such as scars, radiodermatitis, lymphedema, disturbed innervation or mechanical friction etc. Typical and rarer skin disorders associated with them are discussed and illustrated by their observations.CONCLUSION:At this moment, we wish to inform dermatologists and non-dermatologists about Ruocco’s concept and its implications.

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“…Chronic osteomyelitis after limb trauma can lead to malignant transformation known as Marjolin’s ulcer [37].…”

Section: Injection Sites Stings and Bites As An Icdmentioning

confidence: 99%

Immunocompromised Districts of Skin: A Case Series and a Literature Review

Vojvodić

Tirant

Nardo

et al. 2019

Open Access Maced J Med Sci

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Ulcus cruris

et al. 2013

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The lower leg is in particular prone to the development of ulceration. Many different causes may lead to ulceration. Thus, a thorough diagnosis is mandatory, and a biopsy is often required. By far the most common type is the classical venous ulcer due to chronic venous insufficiency, located at the medial ankle. A more complicated-and more difficult to treat-type of venous ulcer is arthrogenic congestion syndrome with its extreme variant of a "legging" ulcer. In cases with severe peripheral arterial disease, an arterial ulcer may develop. The hypertensive ulcer Martorell is associated with arterial hypertension and diabetes; the underlying pathology is occlusion of arteriolar vessels. A typical diabetic ulceration is the necrobiosis lipoidica. Important differential diagnoses of leg ulceration include pyoderma gangrenosum and the calciphylactic ulcer. Due to a long-standing course, an ulceration may turn malignant. Vice versa, ulceration may occur as sign of a primary malignant lesion.

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Malignant tumours arising in chronic leg ulcers: three cases and a review of the literature

Erfurt‐Berge

Bauerschmitz

2011

J Wound Care

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The precancerous potential of chronic leg ulcers is well-established but the number of reported cases overall is small. Delay in diagnosis may result in a worse prognosis, loss of the affected limb or occurrence of metastases. We report a case series of three patients with long-standing history of recalcitrant leg ulcers, which finally showed malignancy when histologically investigated. In addition, we discuss the literature concerning malignant transformation of chronic leg ulcers and try to bring forward the controversial question of how to differentiate primary and secondary malignancies in chronic ulcers. Although hypotheses about altered wound healing mechanisms, influence of chronic inflammation and irritation or tissue damage through infections are conclusive, further investigations are necessary to clarify the exact pathogenetic mechanisms of tumour development in chronic wounds.

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Das Marjolin-Ulkus

Cited by 3 publications

References 19 publications

Immunocompromised Districts of Skin: A Case Series and a Literature Review

Immunocompromised Districts of Skin: A Case Series and a Literature Review

Ulcus cruris

Malignant tumours arising in chronic leg ulcers: three cases and a review of the literature

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