Das extrakraniell metastasierende maligne Gliomiatrogen?

Megele, R; Gruß, Peter; Bührmann, K

doi:10.1055/s-2008-1054027

Cited by 11 publications

(13 citation statements)

References 4 publications

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“…However, the seeding to the skeleton after a long latency in 5 patients cannot be explained simply by haematogenous or lymphatic tumour cell spread after surgical intervention, nor by invasion of the scalp following craniotomy [4,5,8,33,37]. Such extra-axial metastases were invariably found to correlate with the presence of va-shunts [4, 18, 23-25, 32, 49] and indeed 4 of our 5 patients with bone metastases had a va-shunt.…”

Section: Extra-axial Metastasesmentioning

confidence: 79%

Secondary manifestation of medulloblastoma: Metastases and local recurrences in 66 patients

et al. 1995

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Although primary treatment of medulloblastoma is now successful in a high percentage of patients, its secondary manifestations still bear a poor prognosis. Thorough studies of secondary manifestations are therefore pivotal to plan therapeutic approaches for the long-term management of medulloblastoma. Here we describe the incidence of secondary tumour manifestations in 66 patients of a single centre who underwent surgery for medulloblastoma between 1975 and 1990. No patient was excluded due to a poor postoperative course. Thirty-five patients showed evidence of secondary tumour growth. Of these, 17 suffered from local recurrence, and 27 developed metastastatic disease. The median latencies for secondary manifestations were 25 months for local recurrence (n = 17), 11 months for spinal metastases (n = 10), 15 months for supratentorial metastases (n = 8), 8 months for subleptomeningeal dissemination (n = 6), and 23 months for systemic metastases (n = 8). Two patients developed primary metastatic spread to the posterior fossa. Of 8 patients with supratentorial metastases, 6 developed fronto-basal lesions. In our patients, 89% of secondary lesions occurred within less than 3 years after primary diagnosis. 85% of patients with extra-axial tumour spread had been treated with a permanent shunt. Radical tumour resection and radiotherapy with 30 Gy to the neuraxis and 20 Gy boost to the posterior fossa was an important prognostic factor in this series. Patients with additional chemotherapy did not benefit significantly from this treatment. We conclude that optimal management of the primary lesions should aim at (i) total resection, (ii) avoid permanent shunting, and (iii) completion of the radiotherapy with inclusion of the medial frontobasal cisterns in the radiotherapeutic regimen. Our analysis suggests that adequate postoperative screening programmes should consist of 3-monthly scans of the neuraxis in the first three postoperative years and 6-monthly scans thereafter.

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Section: Extra-axial Metastasesmentioning

confidence: 79%

Secondary manifestation of medulloblastoma: Metastases and local recurrences in 66 patients

et al. 1995

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“…Im Folgenden wird der Fall einer Parotismetastase, ausgehend von einem Glioblastom des Schläfenlap-pens, vorgestellt. Im bisherigen internationalen Schriftum konnten nur 3 ähn-liche Fälle recherchiert werden [6,12,14].…”

Section: Seltene Parotistumorenunclassified

“…Als ausgesprochene Rarität unter den Fernmetastasen gelten solche bei intrakraniellem Primärtu-mor. So sind im internationalen Schrifttum nur ein Fall einer Parotismetastase eines Medulloblastoms [21] und 3 Fälle eines Astrozytoms (Grad III und IV) beschrieben [6,12,14].…”

Section: Diskussionunclassified

“…Übereinstimmend mit den vorbeschriebenen Fällen [12,19] war auch bei dem Patienten M.S.der Primärtumor im ipsilateralen Temporallappen lokalisiert. Generell wird als Ursache für eine Fernmetastasierung spekuliert,dass die vorausgegangene Tumorresektion mit Eröffnung der Gefäße von Leptomeninx und Dura für die hämatogene Metastasierung eine entscheidende Rolle spielt [5].…”

Section: Diskussionunclassified

“…Postoperativ konnten zudem im Blut der Patienten Gliomzellen nachgewiesen werden [12]. Eine weitere Möglichkeit für die Metastasierung können intraoperativ ins Subkutangewebe verschleppte Tumorzellen darstellen [12].…”

Section: Diskussionunclassified

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Seltene Parotistumoren

Kühn

Köhler

Jecker

2003

HNO

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Tumors of the parotid gland can be benign or malignant lesions.The pathophysiology of rare tumors of the parotid gland is often not sufficiently explored in this paper two rare histological entities are described. In one patient a benign sebaceous lymph-adenoma was histologically diagnosed. This type of tumor accounts for only 0.196 of all adenomas. The international literature is not conclusive about whether the tumor originates in the parotid gland itself or in the parotid lymph nodes. The second patient presented with a metastasis from a glioblastoma in the parotid gland. Again, the mechanism for metastasis of an intra-cerebral tumor to the parotid gland remains unknown. Iatrogenic seeding during a neurosurgical intervention is a probable explanation. The actual clinical course of his patient and the cases described in literature render surgical removal of such a metastasis questionable.

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Case Reports of Symptomatic Metastases in Four Patients with Primary Intracranial Gliomas

Hübner

Braun

Richter

2001

Acta Neurochirurgica

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Four patients with primary intracranial high-grade gliomas are reported. Three of them developed spinal symptoms and signs generated by spinal metastases a few months after first diagnosis, the last patient developed an extraspinal metastasis in cervical lymph nodes. The spinal metastasis of a 30 years old patient was located intradurally at L5/S1, in the second patient at level L3, the third patient presented with multiple metastases in the cervical, thoracic and lumbar spine. Previously reported cases are reviewed, are discussed in the light of our own observations and analysed for the various therapeutic options.

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Das extrakraniell metastasierende maligne Gliomiatrogen?

Cited by 11 publications

References 4 publications

Secondary manifestation of medulloblastoma: Metastases and local recurrences in 66 patients

Secondary manifestation of medulloblastoma: Metastases and local recurrences in 66 patients

Seltene Parotistumoren

Case Reports of Symptomatic Metastases in Four Patients with Primary Intracranial Gliomas

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