Das experimentelle Asthma bronchiale des Meerschweinchens

Noelpp, B.; Noelpp-Eschenhagen, I.

doi:10.1159/000227964

Cited by 15 publications

(2 citation statements)

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“…Conducted at the same time but less well-known are Romanian studies reporting conditioned increases in the phagocytic activity of polymorphonuclear peripheral blood cells in dogs (42,51). A series of reports was published also at that time by Swiss investigators, who conditioned an asthma-like response using an auditory CS in guinea pigs (333)(334)(335)(336)(337)(338), an experiment later repeated in humans (129). Simultaneously, experimental data provided evidence that a certain context as a CS was able to elicit asthmatic symptoms in guinea pigs (345), which led to the assumption that in some cases asthma might be the result of a conditioning process and is therefore a learned response (469).…”

Section: History Of Learned Immune Responses: the Beginningmentioning

confidence: 99%

Pavlovian Conditioning of Immunological and Neuroendocrine Functions

Hadamitzky

Lückemann

Pacheco-López

et al. 2020

Physiological Reviews

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The phenomenon of behaviorally conditioned immunological and neuroendocrine responses has been investigated for the past 100 years. The observation that peripheral immune functions can be modified by associative learning processes was first reported and investigated by Ivan Petrovic Pavlov and his co-workers. Their work later fell into oblivion, also because so little was known about the immune system's function and even less about the underlying mechanisms of how learning, a central nervous system activity, could affect peripheral immune responses. This phenomenon was re-discovered 45 years ago as one of the most fascinating examples of the reciprocal functional interaction between behavior, the brain, and peripheral immune functions, and it established psychoneuroimmunology as a new research field. Relying on growing knowledge about efferent and afferent communication pathways between the brain, neuroendocrine system, primary and secondary immune organs, and immunocompetent cells, experimental animal studies demonstrate that cellular and humoral immune and neuroendocrine functions can be suppressed or activated via distinct associative learning protocols. These (from the classical perspective) learned immune responses are clinically relevant, since they affect the development and progression of immune-related diseases and, more importantly, are also inducible in humans. The increased knowledge about the neuropsychological machinery steering learning and memory processes together with recent insight into the mechanisms mediating placebo responses provides fascinating perspectives to exploit these learned immune and neuroendocrine responses as supportive therapies, the aim being to reduce the amount of medication required, diminishing unwanted drug side effects while maximizing the therapeutic effect for the patient's benefit.

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Section: History Of Learned Immune Responses: the Beginningmentioning

confidence: 99%

Pavlovian Conditioning of Immunological and Neuroendocrine Functions

Hadamitzky

Lückemann

Pacheco-López

et al. 2020

Physiological Reviews

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“…Romanian researchers around the same period documented the influence of immune activation on a conditioned salivary response as well as putatively conditioned enhancements in the phagocytic activity of To Learn New Things, Read Old Books and Papers polymorphonuclear cells in dogs' peripheral blood [58,59]. In parallel, Swiss scientists released a series of reports demonstrating conditioned asthma-like responses in guinea pigs using auditory CS [22,[60][61][62][63][64]. This experiment was later replicated with human subjects [65].…”

Section: Early Work On Extinction/modulation Of Conditioned Immune Re...mentioning

confidence: 99%

Behaviorally Conditioned Immune Responses: “To Learn New Things, Read Old Books & Papers”

Schedlowski,

Hadamitzky

2024

Neuroimmunomodulation

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More than a century ago, experimental work and clinical observations revealed the functional communication between the brain and the peripheral immune system. This is documented on the one hand by studies firstly demonstrating the effects of catecholamines on the circulation of leukocytes in experimental animals and humans and on the other hand via the work of Russian physiologist Ivan Petrovic Pavlov and his co-workers, reporting observations that associative learning can modify peripheral immune functions. This work later fell into oblivion, since little was known about the endocrine and immune system’s function and even less about the underlying mechanisms of how learning, a central nervous system activity, could affect peripheral immune responses. In this article, we embark on a fascinating exploration of the historical trajectory of behaviorally conditioned immune responses. We'll pay homage to the visionary scientists who laid the groundwork for this field of research, tracing its evolution from early theories of how associative learning can affect immunity to the modern-day insights that behavioral conditioning of pharmacological responses can be exploited to improve the efficacy of medical interventions for patients.

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