Das desmoplastische maligne Melanom

Abstract

Clinical and histopathological findings of 34 cases of desmoplastic malignant melanoma (DMM) are summarized and compared to the literature. DMM develop mostly in sun damaged skin of elderly patients, they are rare and often nonpigmented tumors that are difficult to diagnose clinically. In all cases the tumor parameters showed level IV or V melanomas (level IV: 55.9%, level IV-V: 14.7%, level V: 29.4%) and the tumor thickness measured 3.85 mm +/- 2.31 mm (1.0-11.0 mm). In 22 cases, the follow-up time was between 2 and 7 years. Local recurrences were observed in 7 ( = 31.8%) patients, metastases in 4 ( = 18.2%) and tumor-related deaths in 3. The prognosis for our patients seems to be slightly better than that described in the literature. The main reason is an improved histological diagnosis of this special type of melanoma. Using immunohistochemical staining with anti-S100 antibody it is possible to establish the melanocytic nature of these fibrotic spindle cell tumors earlier that is, in small initial biopsies, and tumor margins can be defined more accurately. As a consequence, surgery is done earlier and is more likely to be curative.

Intracranial Trigeminal Nerve Metastasis of a Desmoplastic Neurotropic Melanoma: Case Report

“…2b , Gomori), corresponding to many collagenous fi bers in the Elastica van Gieson stain. In accordance with the literature [3,12,23] the tumor cells were positive for S-100 protein ( ᭹ ᭤ Fig. 2c ), vimentin and neuron-specifi c enolase (NSE).…”

Paranasal sinus angiosarcoma with facial paralysis as a novel manifestation: a case report and literature review

“…However, in this case, PNI and PNTS are both unlikely to be associated with FP. PNI has been demonstrated as a common pathologic finding in head and neck malignancies, especially in squamous cell carcinoma (25–80%) and adenoid cystic carcinoma (at least 50%) [ 27 – 29 ], while it has not yet been observed in angiosarcoma. Additionally, the typical pathological patterns of PNI include the following: i) tumour cells are close to the nerve and involve at least 33% of the surrounding area and ii) tumour cells are located in the perineural nerve sheath and can differentially infiltrate into the three nerve sheaths [ 30 ].…”