Das Chamäleon der Psychiatrie – Psychiatrische Manifestationsformen der Neurosyphilis

Friedrich, Fabian; Geusau, Alexandra; Friedrich, Michaela-Elena; Vyssoki, Benjamin; Pfleger, Tibor; Aigner, Martin

doi:10.1055/s-0031-1276935

Cited by 10 publications

(9 citation statements)

References 43 publications

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“…Psychotic symptoms in correlation with organic mental disorders due to neurosyphilis are substantially discussed in the recent literature [10,26,27,28,29]. Mannekote and Singh [30] describe a case of neurosyphilis, in which the patient presented with treatment-resistant psychotic symptoms, which responded to antibiotic treatment.…”

Section: Resultsmentioning

confidence: 99%

“…The evidence indicates that an increase in infection rates in industrialized countries of the Western world can be observed too. Taking into account that due to the diversity of clinical manifestations of neurosyphilis it is impossible to carry out a diagnosis only based on the analysis of clinical symptoms, blood screening for syphilis in the psychiatric field seems to be a vital part of diagnostic investigation of psychiatric patients [10,34]. Every patient with clinically evident psychiatric symptoms should have bloodscreening for syphilis, and in the case of positive results a lumbar puncture is indicated.…”

Section: Discussionmentioning

confidence: 99%

“…It is evident that there is no consensus on interdisciplinary diagnostic procedures or on how to diagnose neurosyphilis across different national diagnostic guidelines [10]. As a first step in the development of future treatment options, specific and interdisciplinary diagnostic criteria for neurosyphilis seem to be necessary (e.g.…”

Section: Discussionmentioning

confidence: 99%

“…This may lead to a more rapid progression of syphilis to the stage of neurosyphilis. Consecutively, clinical manifestations may occur even a short time after infection [10,45,46]. However, the organic mental disorder due to assured neurosyphilis has to be considered as the primary diagnostic criterion in every single case.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore it is a differential diagnosis for many psychiatric presentations according to ICD-10 or DSM-IV [9,10]. …”

Section: Introductionmentioning

confidence: 99%

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Psychosis in Neurosyphilis - Clinical Aspects and Implications

et al. 2013

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Background: The World Health Organization estimates that 10-12 million new syphilis infections occur each year. Without treatment, years to decades after initial infection, 30% of affected individuals may develop tertiary syphilis, which can manifest as neurosyphilis. The aim of this review is to evaluate the research literature examining the psychopathological manifestations of psychosis in association with neurosyphilis. Method: The authors performed a systematic electronic search for published studies (1995-2012). The following databases were used: Medline, Embase and the Cochrane Library as well as the search engines Scopus and Google Scholar. Results: 61 articles were used for detailed analysis. Psychotic symptoms due to neurosyphilis are numerous and can inform differential diagnosis for many psychotic manifestations according to ICD-10 or DSM-IV. Conclusion: Due to our results, current epidemiological data, and the difficulties in differential diagnosis of neurosyphilis, routine screening tests are still recommended in the psychiatric field. Long-term psychiatric input, with periodic syphilis titre controls, seems indicated in individuals affected by neurosyphilis with psychiatric symptoms. Furthermore, individuals with mental health problems may be at higher risk of acquiring syphilis.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…Therefore it is a differential diagnosis for many psychiatric presentations according to ICD-10 or DSM-IV [9,10]. …”

Section: Introductionmentioning

confidence: 99%

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Psychosis in Neurosyphilis - Clinical Aspects and Implications

et al. 2013

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Schicksale an der Klagenfurter Psychiatrie im Nationalsozialismus

Oberlerchner

Stromberger

2012

Neuropsychiatr

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In this article the fate of Mr. B. is described as an example for the fate of hundreds of mentally ill patients of the "Landes-Irrenanstalt of Klagenfurt", murdered during the era of National Socialism. This extraordinary fate marks two outstanding aspects of history of medicine, the treatment of syphilis with malaria and the organised mass murder of mentally ill people during the cynic era of National Socialism. Beyond this historical perspective reconstructive biographical work together with relatives is presented as a proactive duty of psychiatric institutions.

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