Das �bergangsverhalten der Herzfrequenz des Menschen in Abh�ngigkeit von der Atemphase w�hrend des schnellen, passiven Lagewechsels

Rossberg, F; Martínez, Luis Eduardo Cruz

doi:10.1007/bf00422168

Cited by 6 publications

(3 citation statements)

References 10 publications

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“…Although the tilt simulations are not synchronized to the respiratory cycle, the simulated transient response of heart rate generally matches the features reported in Ref. 59 within the error bounds of their experiments, the duration of the initial heart rate complex (features 7 and 8) being an exception.…”

Section: Tilt Table Simulationsupporting

confidence: 73%

“…Note, however, that the two studies with the largest number of subjects enrolled generally agree on the timing of heart rate increase and subsequent drop (features 7 and 8 in Fig. 9) whereas the magnitude of the heart rate increase remains controversial (10,59). We chose to compare our simulation results to the study by Rossberg and Martinez (59) because they provide the most detailed numerical analysis of the Fig.…”

Section: Discussionmentioning

confidence: 99%

“…It needs to be pointed out that the transient response of heart rate and blood pressure to rapid tilts has been the focus of many experimental investigations, the results of which seem to fall into two categories: one group of investigations demonstrated a pronounced transient response of heart rate and blood pressure to rapid tilts similar to those seen in standing up (12,58,59,73), whereas a second group of investigations showed a more gradual response to rapid tilts that differ in amplitude and dynamics from the transients encountered during an active change in posture (68)(69)(70). Note, however, that the two studies with the largest number of subjects enrolled generally agree on the timing of heart rate increase and subsequent drop (features 7 and 8 in Fig.…”

Section: Discussionmentioning

confidence: 99%

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Computational modeling of cardiovascular response to orthostatic stress

Heldt

Shim

Kamm

et al. 2002

Journal of Applied Physiology

258

282

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The objective of this study is to develop a model of the cardiovascular system capable of simulating the short-term (< or = 5 min) transient and steady-state hemodynamic responses to head-up tilt and lower body negative pressure. The model consists of a closed-loop lumped-parameter representation of the circulation connected to set-point models of the arterial and cardiopulmonary baroreflexes. Model parameters are largely based on literature values. Model verification was performed by comparing the simulation output under baseline conditions and at different levels of orthostatic stress to sets of population-averaged hemodynamic data reported in the literature. On the basis of experimental evidence, we adjusted some model parameters to simulate experimental data. Orthostatic stress simulations are not statistically different from experimental data (two-sided test of significance with Bonferroni adjustment for multiple comparisons). Transient response characteristics of heart rate to tilt also compare well with reported data. A case study is presented on how the model is intended to be used in the future to investigate the effects of post-spaceflight orthostatic intolerance.

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Section: Tilt Table Simulationsupporting

confidence: 73%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Computational modeling of cardiovascular response to orthostatic stress

Heldt

Shim

Kamm

et al. 2002

Journal of Applied Physiology

258

282

View full text Add to dashboard Cite

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Are heart rate responses reproducible in the tilt-table test?

et al. 1994

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Measurement of blood pressure and heart rate in active orthostasis has proven to be effective in the diagnosis of autonomic regulatory dysfunctions. The following study was carried out in order to clarify to what extent reproducible heart rate reactions also occur in passive orthostasis. 61 people with normal results in five standardized tests were examined. All 61 test persons had individually differing courses of heart rate. After an initial increase of frequency an almost straight line results from a superimposed projection of the graphs. In 20 of these cases the tilt-table test was repeated in order to detect intra-individual regularities. Even when the test was repeated, no reproducible intraindividual heart rate reactions occurred. And here as well, projection of the graphs produced an almost straight line. We could not find any quotient, such as the 30/15 ratio in active orthostasis, during our tests with the tilt-table.

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Initial cardiovascular response on change of posture from squatting to standing

Rossberg

Penaz

1988

Europ. J. Appl. Physiol.

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The immediate cardiovascular responses on active change from the squatting (control) to the standing position differ from those obtained in the lying-to-standing manoeuvre. Without exception, the first beat after changing from squatting to standing showed a decrease in systolic, diastolic and mean pressure by 2.0 +/- 1.1 kPa (14.6 +/- 8.3 mm Hg), 1.4 +/- 1.7 kPa (10.6 +/- 12.6 mm Hg) and 1.9 +/- 1.0 kPa (13.9 +/- 7.3 mm Hg), respectively. During the 4th or 5th pulse after standing the pulse pressure was significantly higher than when lying (P less than 0.01). Mean pressure reached a minimum of 7.7 +/- 1.9 kPa (57.8 +/- 14.4 mm Hg) after 7.1 +/- 1.1 s. Thereafter the blood pressure increased to a new level within about 15 s. 11 of 16 subjects demonstrated a biphasic heart rate (HR) response. The maximum HR was reached after 11.0 +/- 2.4 s of standing. In all experiments, the peaks in HR were distinctly delayed after the blood pressure dips. We conclude that an arterial baroreflex could be implicated in the immediate HR increase after a squatting-to-standing manoeuvre. The subsequent time course of the initial HR response, however, might be induced by other mechanisms.

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Das �bergangsverhalten der Herzfrequenz des Menschen in Abh�ngigkeit von der Atemphase w�hrend des schnellen, passiven Lagewechsels

Cited by 6 publications

References 10 publications

Computational modeling of cardiovascular response to orthostatic stress

Computational modeling of cardiovascular response to orthostatic stress

Are heart rate responses reproducible in the tilt-table test?

Initial cardiovascular response on change of posture from squatting to standing

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