Das aufkommende Konzept des Kohlenstoffisotopenaustauschs

A transition‐metal‐free carbon isotope exchange procedure on phenyl acetic acids is described. Utilizing the universal precursor CO2, this protocol allows the carbon isotope to be inserted into the carboxylic acid position, with no need of precursor synthesis. This procedure enabled the labeling of 15 pharmaceuticals and was compatible with carbon isotopes [14C] and [13C]. A proof of concept with [11C] was also obtained with low molar activity valuable for distribution studies.

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Transition‐Metal‐Free Carbon Isotope Exchange of Phenyl Acetic Acids

Destro

Horkka

Loreau

et al. 2020

Angewandte Chemie

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show abstract

Transition‐Metal‐Free Carbon Isotope Exchange of Phenyl Acetic Acids

et al. 2020

View full text Add to dashboard Cite

A transition‐metal‐free carbon isotope exchange procedure on phenyl acetic acids is described. Utilizing the universal precursor CO 2 , this protocol allows the carbon isotope to be inserted into the carboxylic acid position, with no need of precursor synthesis. This procedure enabled the labeling of 15 pharmaceuticals and was compatible with carbon isotopes [ 14 C] and [ 13 C]. A proof of concept with [ 11 C] was also obtained with low molar activity valuable for distribution studies.

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Das aufkommende Konzept des Kohlenstoffisotopenaustauschs

Cited by 2 publications

References 13 publications

Transition‐Metal‐Free Carbon Isotope Exchange of Phenyl Acetic Acids

Transition‐Metal‐Free Carbon Isotope Exchange of Phenyl Acetic Acids

Transition‐Metal‐Free Carbon Isotope Exchange of Phenyl Acetic Acids

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