Darwinian Selection in Prostate Cancer and Medical Treatment

Song, Chengyan

doi:10.4236/ijcm.2017.86033

Cited by 2 publications

(2 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The low somatic mutation frequency in germline mutated genes could be due to natural selection which is likely to confer selective advantage to specific genes [39]. For example, genomic alteration, clonal selection, and evolution of the tumor microenvironment, may contribute towards unique physiological characteristics under selection pressure contributing to increased mutations in the somatic or tumor genome as observed in this study for the most highly somatic mutated genes, a phenomenon which has been reported in PCa [39]. Although our approach focuses on PCa, the methodology and approach could be applied to other cancers as well.…”

Section: Discussionmentioning

confidence: 99%

Interactions between Germline and Somatic Mutated Genes in Aggressive Prostate Cancer

Mamidi

Hicks

2019

Prostate Cancer

View full text Add to dashboard Cite

Prostate cancer (PCa) is the most common diagnosed malignancy and the second leading cause of cancer-related deaths among men in the USA. Advances in high-throughput genotyping and next generation sequencing technologies have enabled discovery of germline genetic susceptibility variants and somatic mutations acquired during tumor formation. Emerging evidence indicates that germline variations may interact with somatic events in carcinogenesis. However, the possible oncogenic interactions and cooperation between germline and somatic variation and their role in aggressive PCa remain largely unexplored. Here we investigated the possible oncogenic interactions and cooperation between genes containing germline variation from genome-wide association studies (GWAS) and genes containing somatic mutations from tumor genomes of 305 men with aggressive tumors and 52 control samples from The Cancer Genome Atlas (TCGA). Network and pathway analysis were performed to identify molecular networks and biological pathways enriched for germline and somatic mutations. The analysis revealed 90 functionally related genes containing both germline and somatic mutations. Transcriptome analysis revealed a 61-gene signature containing both germline and somatic mutations. Network analysis revealed molecular networks of functionally related genes and biological pathways including P53, STAT3, NKX3-1, KLK3, and Androgen receptor signaling pathways enriched for germline and somatic mutations. The results show that integrative analysis is a powerful approach to uncovering the possible oncogenic interactions and cooperation between germline and somatic mutations and understanding the broader biological context in which they operate in aggressive PCa.

show abstract

Section: Discussionmentioning

confidence: 99%

Interactions between Germline and Somatic Mutated Genes in Aggressive Prostate Cancer

Mamidi

Hicks

2019

Prostate Cancer

View full text Add to dashboard Cite

show abstract

“…The levels of H19 increased in various cancers, such as gastric and gallbladder carcinomas [89,90,91]. Other lncRNAs, such as PCGEM1, HOTAIR, and AK001796, were overexpressed in most cases of prostate cancer and phytochemical-induced anticancer activities [82,103,112,113]. Additionally, the role of HULC in promoting oral and liver cancers was proposed [75,76,114].…”

Section: Introductionmentioning

confidence: 99%

Phytochemicals as Modulators of Long Non-Coding RNAs and Inhibitors of Cancer-Related Carbonic Anhydrases

Saghafi

Taheri

Parkkila

et al. 2019

IJMS

View full text Add to dashboard Cite

Long non-coding RNAs (lncRNAs) are classified as a group of transcripts which regulate various biological processes, such as RNA processing, epigenetic control, and signaling pathways. According to recent studies, lncRNAs are dysregulated in cancer and play an important role in cancer incidence and spreading. There is also an association between lncRNAs and the overexpression of some tumor-associated proteins, including carbonic anhydrases II, IX, and XII (CA II, CA IX, and CA XII). Therefore, not only CA inhibition, but also lncRNA modulation, could represent an attractive strategy for cancer prevention and therapy. Experimental studies have suggested that herbal compounds regulate the expression of many lncRNAs involved in cancer, such as HOTAIR (HOX transcript antisense RNA), H19, MALAT1 (metastasis-associated lung adenocarcinoma transcript 1), PCGEM1 (Prostate cancer gene expression marker 1), PVT1, etc. These plant-derived drugs or phytochemicals include resveratrol, curcumin, genistein, quercetin, epigallocatechin-3-galate, camptothcin, and 3,3′-diindolylmethane. More comprehensive information about lncRNA modulation via phytochemicals would be helpful for the administration of new herbal derivatives in cancer therapy. In this review, we describe the state-of-the-art and potential of phytochemicals as modulators of lncRNAs in different types of cancers.

show abstract

Darwinian Selection in Prostate Cancer and Medical Treatment

Cited by 2 publications

References 55 publications

Interactions between Germline and Somatic Mutated Genes in Aggressive Prostate Cancer

Interactions between Germline and Somatic Mutated Genes in Aggressive Prostate Cancer

Phytochemicals as Modulators of Long Non-Coding RNAs and Inhibitors of Cancer-Related Carbonic Anhydrases

Contact Info

Product

Resources

About