Darwinian Evolution of Self-Replicating DNA in a Synthetic Protocell
Zhanar Abil,
Ana María Restrepo Sierra,
Andreea R. Stan
et al.
Abstract:Replication, heredity, and evolution are characteristic of Life. We and others have postulated that the reconstruction of a synthetic living system in the laboratory will be contingent on the development of a genetic self-replicator capable of undergoing Darwinian evolution. Although DNA-based life dominates, the in vitro reconstitution of an evolving DNA self-replicator has remained challenging. We hereby emulate in liposome compartments the principles according to which life propagates information and evolve… Show more
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