Darunavir ethanolate: Repurposing an anti-HIV drug in COVID-19 treatment

Chavda, Vivek P.; Gajjar, Normi D.; Shah, Nirav; Dave, Divyang

doi:10.1016/j.ejmcr.2021.100013

Cited by 30 publications

(16 citation statements)

References 93 publications

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“…As of January 31, 2022, more than 8 billion vaccine doses have been delivered globally. Many drugs are repurposed, and vaccines are approved based on emergency use approval path to combat the pandemic ( Chavda and Apostolopoulos, 2021 ; Chavda et al, 2021 ; Chavda, Vora, and Vihol, 2021 ; Chavda et al, 2021 ; Chavda et al, 2021 ). Even though there is a disparity in vaccination efforts in various nations, every effort is being made to manage and prevent this infection ( World Health Organization, 2021 ).…”

Section: Current Global Scenario Of Covid-19mentioning

confidence: 99%

Herbal Remedies, Nutraceuticals, and Dietary Supplements for COVID-19 Management: An Update

Chavda

Patel

Vihol

et al. 2022

Clinical Complementary Medicine and Pharmacology

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Currently, the world is facing a coronavirus pandemic with a grave deficiency of specific therapy for coronavirus disease (COVID-19). Moreover, scientists attempt to discover the most refined approach to prevent this condition. Regarding COVID-19 infection, herbal medicines with immunomodulatory effects may offer patients a promising preventive treatment option. Several ayurvedic and traditional Chinese medicines (TCM) are effective during this worrisome coronavirus pandemic i.e. Tinospora cordifolia (Willd.) Miers, Withania somnifera (L.) Dunal, Scutellaria baicalensis Georgi, Curcuma longa L. etc. TCM was shown to be utilized with over 90% efficacy when the COVID-19 pandemic broke out in early 2020. In addition to herbal treatments and nutraceutical drugs, dietary supplements such as vitamins and amino acid derivatives also play a significant part in COVID-19 management. Diet can assist in regulating inflammation, while nutraceuticals can aid in the prevention of viral invasion. Functional amino acids (e.g., arginine, cysteine, glutamate, glutamine, glycine, taurine and tryptophan) and glutathione, which are all abundant in animal-sourced foodstuffs, are crucial for optimum immunity and health in humans and animals. The goal of this article is to thoroughly evaluate recent statistics on the effectiveness of herbal medicines in COVID-19, the antiviral activity of nutraceuticals, and the significance of these results in creating dietary supplements that would enhance innate immunity and contribute as preventive measures against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

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Section: Current Global Scenario Of Covid-19mentioning

confidence: 99%

Herbal Remedies, Nutraceuticals, and Dietary Supplements for COVID-19 Management: An Update

Chavda

Patel

Vihol

et al. 2022

Clinical Complementary Medicine and Pharmacology

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“… 7 S (Spike) proteins are required for entry of COVID‐19 virus into host cells. 8 NSP 14 performs proofreading for the SARS‐CoV‐2 virus. Mutations are always to be anticipated, despite the fact that not all mutations are purposeful or advantageous to the virus.…”

Section: Introductionmentioning

confidence: 99%

“…Considering a growing frequency of instances identified viral variants with mutation sites in the viral spike protein's receptor‐binding domain (RBD) region have garnered widespread interest, the RBD is the primary focus of neutralizing antibodies generated after infection of SARS‐CoV‐2. 8 , 11 , 12 , 13 , 14 , 15 Some abnormalities in the S protein, like those reported in the N‐terminal domain (NTD), may also affect neutralizing antibody capacity. 16 A reconstituted SARS‐CoV‐2 (virus or genetic mutant) may have additional mutations that separate it from the basic pattern or common viral variants widely circulated in humans.…”

Section: Introductionmentioning

confidence: 99%

SARS‐CoV‐2 variants and vulnerability at the global level

Chavda

Patel

Vaghasiya

2022

Journal of Medical Virology

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Numerous variants of the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) pandemic have evolved. As viral variants may evolve with harmful susceptibility to the immunity established with the existing COVID‐19 vaccination, these variations are more transmissible, induce relatively extreme illness, have evasive immunological features, decrease neutralization using antibodies from vaccinated persons, and are more susceptible to re‐infection. The Centers for Disease Control and Prevention (CDC) has categorized SARS‐CoV‐2 mutations as variants of interest (VOI), variants of concern (VOC), and variants of high consequence (VOHC). At the moment, four VOC and many variants of interest have been defined and require constant observation. This review article summarizes various variants of SARS‐CoV‐2 surfaced with special emphasis on VOCs that are spreading across the world, as well as several viral mutational impacts and how these modifications alter the properties of the virus.

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“…As of February 2022, over 5 million SARS-CoV-2 RNA genomes had been shared through the global initiative on sharing all influenza data [ 10 , 11 ]. A number of nonspecific and broad-spectrum antivirals and anti-inflammatory medicines, supportive care and vaccines have been translated into human studies at unprecedented speeds [ 12 , 13 ]. Thus, patients suffering from critical COVID-19 infection are given antivirals (such as remdesivir), monoclonal antibodies (sotrovimab, bamlanivimab, etesevimab, asiriviamb, imdevimab), IL-6 and IL-1 inhibitors, mechanical ventilation and corticosteroids (inhalation, tablet or injection) [ 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

A Global Picture: Therapeutic Perspectives for COVID-19

et al. 2022

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The COVID-19 pandemic is a lethal virus outbreak by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), which has severely affected human lives and the global economy. The most vital part of the research and development of therapeutic agents is to design drug products to manage COVID-19 efficiently. Numerous attempts have been in place to determine the optimal drug dose and combination of drugs to treat the disease on a global scale. This article documents the information available on SARS-CoV-2 and its life cycle, which will aid in the development of the potential treatment options. A consolidated summary of several natural and repurposed drugs to manage COVID-19 is depicted with summary of current vaccine development. People with high age, comorbity and concomitant illnesses such as overweight, metabolic disorders, pulmonary disease, coronary heart disease, renal failure, fatty liver and neoplastic disorders are more prone to create serious COVID-19 and its consequences. This article also presents an overview of post-COVID-19 complications in patients.

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Darunavir ethanolate: Repurposing an anti-HIV drug in COVID-19 treatment

Cited by 30 publications

References 93 publications

Herbal Remedies, Nutraceuticals, and Dietary Supplements for COVID-19 Management: An Update

Herbal Remedies, Nutraceuticals, and Dietary Supplements for COVID-19 Management: An Update

SARS‐CoV‐2 variants and vulnerability at the global level

A Global Picture: Therapeutic Perspectives for COVID-19

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