“…[7] In this context, a straightforward method to generate trifluoromethylated and unsymmetrically substituted hydrazines would be particularly impactful, owing to the powerful effects of fluorination on the (metabolic) stabilities as well as physical properties of organic molecules. [8] However, the current methodological repertoire to access N-CF 3 hydrazines is of limited scope [9,10] (see Figure 1, middle), relying on harsh photolysis or unselective oxidations with XeF 2 (to yield I) as well as pyrolysis to yield polytrifluoromethylated hydrazines (III), or low-yielding trifluoromethylation of a single class of diazo compounds (to yield II), for which the feasibility of Boc deprotection and potential derivatizations has not been demonstrated however. [10g] In this context, we envisioned that if we could develop a general method to access pharmaceutically and agrochemically relevant aromatic N-CF 3 hydrazines, this might poten-tially allow us to unlock valuable and currently inaccessible N-CF 3 derivatives, such as N-CF 3 hydrazones, sulfonyl hydrazines, or indoles.…”