Darier's disease involving an epidermoid cyst

Abstract

Histological signs of Darier's disease, including 'corps ronds', 'grains', and acantholytic clefts are demonstrated in the wall of an epidermoid cyst in a patient with Darier's disease of the skin. Possible mechanisms in the development of cyst wall changes are discussed.

Proliferations of the epidermoid cyst wall

“…Histologic signs of Darier's disease, including ''corps ronds'', ''grains,'' and acantholytic clefts, have been observed in the wall of an EC in a patient with Darier's disease of the skin. 26 In a case of unilateral porokeratosis of Mibelli, light microscopy revealed a cyst-like dilation in the upper corium containing two cornoid lamella complexes. 27 The typical histologic features of psoriasis have been described in the wall of an EC and considered as an inside Koebner phenomenon.…”

“…47 In addition to the cysts in patients with Gardner's syndrome, in which it is possible to observe foci similar to pilomatricoma, 5,6 clinical and pathologic features of pilomatricoma associated with ECs have been described without features of Gardner's syndrome. 26 International Journal of Dermatology 1998, 37, 181-185 © 1998 Blackwell Science Ltd…”