Darbepoetin Alfa Administered Once Every Three Weeks for the Treatment of Anemia in Elderly Patients with Non-myeloid Tumors Receiving Chemotherapy

Abstract

The study results suggest that DA is an effective and well-tolerated therapy for the treatment of chemotherapy-induced anemia in elderly patients.

Effects of Long- and Short-term Darbepoetin-α Treatment on Oxidative Stress, Inflammation and Endothelial Injury in Apo E Knockout Mice

“…Darbepoetin-α protects renal tissue against the adverse effects of ischaemia, provides well-tolerated therapy for the treatment of chemotherapy-induced anemia and reduces lipopolysac-charide-induced hepatocellular apoptosis. [10][11][12] Darbepoetin-α reduces infarcted myocardium size, weakens cardiomyocyte apoptosis and enhances cardiac function. 13 The effects of darbepoetin-α on the biochemical parameters of atherosclerosis and histopathological lesions in apolipoprotein E knockout (ApoE −/− ) mice are not known.…”