Daptomycin, Methicillin Resistant <i>Staphylococcus hominis</i> Catheter-Related Bacteraemia in a Hemodialysis Patient

Abstract

We report a case of a haemodialysis patient that presented a catheter-related bacteraemia caused by a Coagulase negative Staphylococcus. With the utilization of molecular biology techniques the bacterial isolate recovered from catheter was surprisingly identified as S. hominis by sequencing of the 16S ribosomal gene. The S. hominis isolate, which is not often associated with infections in dialysis patients, was resistant to methicillin, being mecA positive, and to daptomycin. The patient was successfully treated with vancomycin together with the catheter retirement.

Whole-Genome Sequence of Staphylococcus hominis Strain J31 Isolated from Healthy Human Skin

“…S. hominis is a reservoir for mobile genetic elements, such as the staphylococcal cassette chromosome mec element (SCC mec ), which harbors the mecA gene for methicillin resistance ( 1 ). The presence of multidrug resistance phenotypes was identified in the population ( 7 , 8 ), which is significant given the increasing rates of nosocomial S. hominis infections ( 7 , 9 , 10 ). Efforts to understand the role of S. hominis in human health and disease are significantly earlier in their infancy than those of Staphylococcus aureus , S. epidermidis , and Staphylococcus haemolyticus .…”