Daptomycin is more efficacious than vancomycin against a methicillin-susceptible Staphylococcus aureus in experimental meningitis

Gerber, Peter; Stucki, Andreas; Acosta, Fernando; Cottagnoud, Marianne; Cottagnoud, Philippe

doi:10.1093/jac/dkl007

Cited by 71 publications

(47 citation statements)

References 23 publications

(22 reference statements)

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“…None of the CSF samples from the ceftriaxone group were sterile at the end of the treatment period. The data confirmed the efficacy of daptomycin in experimental meningitis, as demonstrated in previous studies (2,6). We are aware that the standard regimen for pneumococcal meningitis due to penicillin-resistant strains consists of a combination of ceftriaxone plus vancomycin and not of ceftriaxone monotherapy, but the aim of this study was to compare a bacteriolytic with a nonbacteriolytic regimen.…”

supporting

confidence: 83%

Daptomycin Produces an Enhanced Bactericidal Activity Compared to Ceftriaxone, Measured by [ ³ H]Choline Release in the Cerebrospinal Fluid, in Experimental Meningitis Due to a Penicillin-Resistant Pneumococcal Strain without Lysing Its Cell Wall

Stucki

Cottagnoud

Winkelmann

et al. 2007

Antimicrob Agents Chemother

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Daptomycin monotherapy was superior to ceftriaxone monotherapy and was highly efficacious in experimental pneumococcal meningitis, sterilizing the cerebrospinal fluid (CSF) of three of three rabbits after 4 to 6 h. With daptomycin therapy only a negligible release of [3H]choline as marker of cell wall lysis was detectable in the CSF, peaking around 250 cpm/min after 4 h, compared to a peak of around 2,400 cpm/min after 4 to 6 h for the ceftriaxone-treated rabbits.

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supporting

confidence: 83%

Daptomycin Produces an Enhanced Bactericidal Activity Compared to Ceftriaxone, Measured by [ ³ H]Choline Release in the Cerebrospinal Fluid, in Experimental Meningitis Due to a Penicillin-Resistant Pneumococcal Strain without Lysing Its Cell Wall

Stucki

Cottagnoud

Winkelmann

et al. 2007

Antimicrob Agents Chemother

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“…This is even more of an issue when the vancomycin MIC of an MRSA isolate approaches or exceeds 2 g/ml. In such dire settings, consideration can be given to unproven adjunctive therapies such as the intrathecal administration of vancomycin (796,797) or the addition of antibiotics such as linezolid (CSF penetration, 66% [79]), TMP-SMX (CSF penetration, ϳ50% [798]), or daptomycin (CSF penetration, 6% [799]). …”

Section: Meningitismentioning

confidence: 99%

Staphylococcus aureus Infections: Epidemiology, Pathophysiology, Clinical Manifestations, and Management

et al. 2015

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SUMMARY Staphylococcus aureus is a major human pathogen that causes a wide range of clinical infections. It is a leading cause of bacteremia and infective endocarditis as well as osteoarticular, skin and soft tissue, pleuropulmonary, and device-related infections. This review comprehensively covers the epidemiology, pathophysiology, clinical manifestations, and management of each of these clinical entities. The past 2 decades have witnessed two clear shifts in the epidemiology of S. aureus infections: first, a growing number of health care-associated infections, particularly seen in infective endocarditis and prosthetic device infections, and second, an epidemic of community-associated skin and soft tissue infections driven by strains with certain virulence factors and resistance to β-lactam antibiotics. In reviewing the literature to support management strategies for these clinical manifestations, we also highlight the paucity of high-quality evidence for many key clinical questions.

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“…Then, rabbits were separated into three groups: the daptomycin (D) group received one dose of 15 mg/kg daptomycin, and the vancomycin (V) group received 20 mg/kg vancomycin two times (4 h apart) through a peripheral ear vein. The control (C) group did not receive any drug treatment (4).…”

mentioning

confidence: 99%

“…CSF and serum drug levels were measured by a bioassay technique in samples obtained at 8 hours after drug treatment (2,4). At the end of the study period (8 h after the initiation of drug treatment), animals were humanely killed by intravenous infusion of a high dose of nembutal.…”

mentioning

confidence: 99%

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Daptomycin versus Vancomycin in Treatment of Methicillin-Resistant Staphylococcus aureus Meningitis in an Experimental Rabbit Model

Bardak-Özcem

Turhan

Sıpahi

et al. 2013

Antimicrob Agents Chemother

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In this study, we aimed to compare the antibacterial activities of daptomycin and vancomycin in the treatment of methicillinresistant Staphylococcus aureus (MRSA) meningitis (induced by MRSA strain ATCC 43300) in an experimental rabbit meningitis model. After an 8-h period of treatment, bacterial counts decreased significantly in both treatment groups compared to the control group (P < 0.05). However, there was no statistically significant difference between treatment groups. Our results suggest that the antibacterial activity of daptomycin is similar to vancomycin for treatment in the experimental MRSA meningitis model in rabbits. Staphylococcus aureus can cause community-acquired and nosocomial bacterial meningitis and is associated with significant mortality. Methicillin-resistant S. aureus (MRSA) is one of the major etiologic agents in hospital-acquired central nervous system infections. Since the available treatment options are limited, therapy of MRSA meningitis is problematic (1). The aim of this study was to compare the efficacies of vancomycin and daptomycin in MRSA meningitis in an experimental rabbit meningitis model.Bacterial strain. S. aureus ATCC 43300 (vancomycin MIC, 1 mg/liter; daptomycin MIC, 0.064 mg/liter [measured in duplicate using the Etest; AB Biodisk, Solna, Sweden]) was used as the infecting bacterial strain (2).The bacterial solution was prepared in 0.9% NaCl at a concentration of 10 6 CFU/ml as described elsewhere (2, 3). Antimicrobial agents. The drugs used were vancomycin (Lilly, Indianapolis, IN) and daptomycin (Novartis Pharma AG, Basel, Switzerland).Rabbit meningitis model. New Zealand White rabbits weighing 2.5 to 3.0 kg were anesthetized by intramuscular injections of ketamine (35 mg/kg of body weight) and xylazine (5 mg/kg) before each intraventricular intervention, including induction of meningitis and cerebrospinal fluid (CSF) sampling (2). The duration of anesthesia was 10 to 15 min. Then, 0.5 ml of the bacterial solution of MRSA was injected directly into the cisterna magna of each rabbit by using a 22-gauge spinal needle (Hayat Ticaret, Istanbul, Turkey).Animals were not anesthetized after the primary inoculation or between the CSF sampling procedures. In addition, they were kept in their cages, except during intraventricular interventions.Sixteen hours after the inoculation, meningitis criteria were determined. CSF white cell counts of more than 1,000/mm 3 (counted by using a Thoma slide) and a bacterial count of Ն10 3 CFU/ml were accepted as the indications of meningitis. Then, rabbits were separated into three groups: the daptomycin (D) group received one dose of 15 mg/kg daptomycin, and the vancomycin (V) group received 20 mg/kg vancomycin two times (4 h apart) through a peripheral ear vein. The control (C) group did not receive any drug treatment (4).Quantitative bacterial cultures were prepared from CSF samples, which were obtained at the beginning and at 8 hours after treatment. CSF and serum drug levels were measured by a bioassay technique in samples obtained at ...

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Daptomycin is more efficacious than vancomycin against a methicillin-susceptible Staphylococcus aureus in experimental meningitis

Abstract: The superior bactericidal activity of daptomycin was confirmed in vivo and in time-killing assays in vitro.

Cited by 71 publications

References 23 publications

Daptomycin Produces an Enhanced Bactericidal Activity Compared to Ceftriaxone, Measured by [ ³ H]Choline Release in the Cerebrospinal Fluid, in Experimental Meningitis Due to a Penicillin-Resistant Pneumococcal Strain without Lysing Its Cell Wall

Daptomycin Produces an Enhanced Bactericidal Activity Compared to Ceftriaxone, Measured by [ ³ H]Choline Release in the Cerebrospinal Fluid, in Experimental Meningitis Due to a Penicillin-Resistant Pneumococcal Strain without Lysing Its Cell Wall

Staphylococcus aureus Infections: Epidemiology, Pathophysiology, Clinical Manifestations, and Management

Daptomycin versus Vancomycin in Treatment of Methicillin-Resistant Staphylococcus aureus Meningitis in an Experimental Rabbit Model

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Daptomycin is more efficacious than vancomycin against a methicillin-susceptible Staphylococcus aureus in experimental meningitis

Abstract: The superior bactericidal activity of daptomycin was confirmed in vivo and in time-killing assays in vitro.

Cited by 71 publications

References 23 publications

Daptomycin Produces an Enhanced Bactericidal Activity Compared to Ceftriaxone, Measured by [ 3 H]Choline Release in the Cerebrospinal Fluid, in Experimental Meningitis Due to a Penicillin-Resistant Pneumococcal Strain without Lysing Its Cell Wall

Daptomycin Produces an Enhanced Bactericidal Activity Compared to Ceftriaxone, Measured by [ 3 H]Choline Release in the Cerebrospinal Fluid, in Experimental Meningitis Due to a Penicillin-Resistant Pneumococcal Strain without Lysing Its Cell Wall

Staphylococcus aureus Infections: Epidemiology, Pathophysiology, Clinical Manifestations, and Management

Daptomycin versus Vancomycin in Treatment of Methicillin-Resistant Staphylococcus aureus Meningitis in an Experimental Rabbit Model

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Daptomycin Produces an Enhanced Bactericidal Activity Compared to Ceftriaxone, Measured by [ ³ H]Choline Release in the Cerebrospinal Fluid, in Experimental Meningitis Due to a Penicillin-Resistant Pneumococcal Strain without Lysing Its Cell Wall

Daptomycin Produces an Enhanced Bactericidal Activity Compared to Ceftriaxone, Measured by [ ³ H]Choline Release in the Cerebrospinal Fluid, in Experimental Meningitis Due to a Penicillin-Resistant Pneumococcal Strain without Lysing Its Cell Wall