Daptomycin-induced rhabdomyolysis complicated with acute gouty arthritis

Abdelnabi, Mahmoud; Leelaviwat, Natnicha; Liao, En-Dien; Motamedi, Sheedeh; Pangkanon, Watsachon; Nugent, Kenneth

doi:10.1016/j.amjms.2023.01.005

Cited by 3 publications

(1 citation statement)

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“…These combined benefits of exercise contribute to lower UA levels and decreased risk of gout attacks. However, it's worth noting that intense exercise may potentially reduce UA solubility by elevating lactate concentration [63], induce dehydrated HU [64], and increase the risk of rhabdomyolysis through the release of UA from skeletal muscle [65]. Therefore, consulting a healthcare professional before starting an exercise regimen is advised, especially for those with medical conditions.…”

Section: Role Of Lifestyle Factorsmentioning

confidence: 99%

Hyperuricemia: Current State and Prospects

Zhang

2024

Preprint

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Hyperuricemia (HU), characterized by elevated uric acid (UA) levels in the blood, represents a global health concern associated with various conditions, including cardiovascular diseases, gout, hypertension, metabolic syndrome, renal dysfunction, and neurodegenerative diseases. This review offers a contemporary analysis of HU, encompassing its causes, associated health risks, diagnosis, treatment, and future outlook. Recent studies have underscored the multifaceted origin of HU, implicating genetic predisposition, dietary patterns, lifestyle choices, and environmental influences. Genetic variations affecting enzymes and transporters involved in purine metabolism and UA excretion have been identified, laying the groundwork for personalized treatment strategies. Advances in diagnostic imaging and omics technologies provide enhanced precision in the detection and evaluation of risks. While pharmacological interventions remain central to managing HU, persistent challenges such as treatment resistance prompt exploration of novel drug targets and lifestyle modifications. Chinese herbal medicines offer a potentially alternative approach with fewer side effects. Emerging research on the impact of gut microbiota on UA metabolism opens new therapeutic avenues. Despite progress, challenges such as optimizing treatment duration and understanding long-term effects persist. Collaborative efforts are crucial to address these challenges and advance our comprehension of HU. The integration of precision medicine and holistic patient care approaches holds promise for improving outcomes and enhancing quality of life for individuals with HU.

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Section: Role Of Lifestyle Factorsmentioning

confidence: 99%