Daptomycin-induced eosinophilia without pulmonary involvement

Doan, Thien-Ly; DePetrillo, John C.; Singer, Carol

doi:10.2146/ajhp090587

Cited by 5 publications

(1 citation statement)

References 7 publications

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“…A quandary exists in this patient's course of treatment that seemingly defies the surface understanding of the pharmacotherapy and pathophysiology involved in this case: that eosinophilia, exacerbated by daptomycin, may be reasonably expected to increase the likelihood of symptomatic asthma due to the rise in eosinophils, especially in the pulmonary system. 6,15 The absence of steroid therapy in this patient during the timeframe in question removes a significant confounding variable. One possible explanation of this patient's unique treatment course can be attributed to cytokine modulation by glycopeptide/lipopeptide antibiotics.…”

Section: Discussionmentioning

confidence: 99%

Implications of Glycopeptide and Lipopeptide Antibiotics on Asthma Exacerbations in a Patient With Hyper-IgE Syndrome and Chronic Severe Asthma: A Case Report

Reinert

Burnham

2020

Journal of Pharmacy Technology

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Objective: To review and consider the immunomodulatory ramifications of glycopeptide and lipopeptide antibiotics in a patient with severe asthma, hyper-immunoglobulin E (IgE) syndrome, and osteonecrosis of the jaw. Case Summary: A 36-year-old male patient with a pertinent past medical history of hyper-IgE syndrome, severe asthma, and osteonecrosis of the jaw attributed to steroid use initially presented to the emergency department, where imaging of the jaw suggested an infectious process. Following months of vancomycin therapy as an outpatient, the patient was switched to daptomycin to facilitate once-daily infusions. Following this change, the patient experienced significantly less asthma exacerbations and fewer admissions to the hospital for asthma-related issues. Discussion: Though daptomycin is associated with eosinophilia, and this patient’s eosinophil counts did increase while on the drug, an inverse relationship developed concerning the number of hospital admissions for asthma exacerbations. A review of the literature indicates that select glycopeptides, such as vancomycin, have pro-inflammatory effects, while other related drugs, such as the lipopeptide daptomycin, may not result in clinical manifestations of an inflammatory process. Tumor necrosis factor-α, interleukin-1β, and interleukin-6 have been implicated in this process. This patient may have been particularly susceptible to the effects of the glycopeptides due to his diagnosis of hyper-IgE syndrome, which has been independently associated with reactive airway diseases. Conclusion: Cytokine migration and activation by select glycopeptide and lipopeptide antibiotics warrant consideration from clinicians when determining the most appropriate treatment regimens. Further research is required to elucidate whether the pro-inflammatory properties of vancomycin warrant a change in first-line therapy to daptomycin in select cases.

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Section: Discussionmentioning

confidence: 99%