Daptomycin cure after cefazolin treatment failure of Methicillin-sensitive Staphylococcus aureus (MSSA) tricuspid valve acute bacterial endocarditis from a peripherally inserted central catheter (PICC) line

Pacemaker-induced Staphylococcus aureus mitral valve acute bacterial endocarditis complicated by persistent bacteremia from a coronary stent: Cure with prolonged/high-dose daptomycin without toxicity

“…Daptomycin is equally effective against MSSA and MRSA strains causing bacteremia or endocarditis. [26][27][28][29][30][31] This patient's strain of MSSA was not resistant to daptomycin and in fact was found to be very susceptible by E-test, ie, MIC of .5 g/mL. Using 6 mg/kg, peak serum concentrations of approximately 99 g/mL are readily achievable and far in excess of what would be necessary to eradicate a strain of MSSA with an MIC of 0.5 g/mL.…”

Daptomycin Antibiotic Lock Therapy in a Rat Model of Staphylococcal Central Venous Catheter Biofilm Infections

“…Daptomycin ALT has not been studied clinically. However, a recent case report demonstrated that daptomycin treatment of catheter-related MSSA acute endocarditis led to a cure after the failure of 3 weeks of high-dose cefazolin treatment to eradicate a tricuspid valve vegetation (10). Another case report showed that high-dose, prolonged therapy with daptomycin resolved both pacemaker-induced S. aureus acute bacterial endocarditis and persistent S. aureus bacteremia resulting from an infected coronary stent (9).…”

Persistent methicillin-sensitive Staphylococcus aureus (MSSA) bacteremia due to a linezolid “tolerant” strain

“…6,7 Although there have been reports of in vivo development of resistance to daptomycin, usually such strains were previously exposed to vancomycin. 8 It is known that vancomycin induces cell wall thickening that may render the strain less susceptible/resistant to vancomycin.…”