Dapsone in the treatment of miliary lupus of the face

Abstract

SUMMARY In an uncontrolled study of twelve patients with miliary lupus of the face, dapsone gave good therapeutic results. Miliary lupus of the face (MLF) is an asymptomatic papular eruption affecting the central area of the face, which runs a chronic course and involutes spontaneously with scarring. Histopathologically, the papules usually show scattered masses of tuberculoid granulomata composed of epithelioid cells, giant cells, and an encircling rim of small round mononuclear cells in the dermis. The actiology and pathogenesis of this condition are still unknown. The treatment of MLF has not been satisfactory despite the use of many topical and systemic agents. In this paper we report that dapsone has been found to be beneficial in the treatment of MLF and has accelerated its resolution in twelve patients.

The treatment of acne agminata with clofazimine

“…4 Dapsone was of some bene®t in 12 patients, appearing to shorten the course. 5 We believe that this is the ®rst report of clofazimine being used in acne agminata. The rapid resolution of the active papules after a short course of treatment and the sustained remission suggest that clofazimine should be considered early in the disease to minimize scarring.…”

Estudio Descriptivo: Granulomas Faciales Idiopáticos con Evolución Regresiva, ¿Es el Lupus Miliar Diseminado Facial un Sinónimo?

“…Muchos autores también han relacionado a esta dermatosis con la sarcoidosis, en especial con la variedad maculopapulosa [14], sin embargo la ausencia de compromiso sistémico, valores normales de enzima convertidora de angiotensina, falta de compromiso de cicatrices antiguas y por último el comportamiento autoinvolutivo con cicatriz residual puntiforme del FIGURE, descartan su vinculación [15].…”

Erythematous, firm, papular eruptions involving the face, neck and chest

“…Drugs tried in its treatment include Isotretinoin, [1] Dapsone, [3] low dose prednisolone [4] and Clofazamine. [5]…”