Dante: A Randomised Trial on Early Diagnosis of Lung Cancer With Low-dose Spiral CT (LDCT); Initial Announcemen

Cancer-Specific Mortality, All-Cause Mortality, and Overdiagnosis in Lung Cancer Screening Trials: A Meta-Analysis

“…The quality of the 9 randomized controlled trials is summarized in Table 1. 5,7,8,11,12,[18][19][20][21] One of these trials 12 had a large imbalance between the number of patients in the screening and control groups (3,512 vs 3,145) and provided no details regarding randomization procedures or concealment of allocation. Such a large imbalance is inconsistent with proper randomization, allocation concealment, or both, and we therefore excluded this trial from further analyses because of its high risk of bias.…”

“…After excluding the trial with high risk of bias, we were left with 8 trials having a total of 90,475 patients. 5,7,8,11,[18][19][20][21] Characteristics of these trials are summarized in Table 2. The trials ranged in size from 2,450 to 53,454 patients, and typically recruited patients with 20 to 30 or more pack-years of smoking and who were currently smoking or had quit no more than 10 to 15 years ago.…”

“…5 The NLST results were published in 2011, and in 2013, the US Preventive Services Task Force recommended lung cancer screening using LDCT for persons aged 55 to 80 years old with a 30-pack-year smoking history who were current smokers or who had quit smoking in the past 15 years. 6 LUNG C A NC ER S CR EENING ME TA -A NA LY SIS The next 2 large randomized controlled trials, published in 2015, found no reduction in lung cancer-specific or all-cause mortality, however, with relative risks (RRs) for lung cancer-specific mortality of 1.01 (95% CI, 0.70-1.44) in the Italian Detection and Screening of Early Lung Cancer With Novel Imaging Technology (DANTE) trial 7 and 1.03 (95% CI, 0.66-1.60) in the Danish Lung Cancer Screening Trial (DLCST). 8 A 2019 meta-analysis identified only 5 studies with mortality results.…”

Chaperonin (HSP60) and annexin-2 are candidate biomarkers for non-small cell lung carcinoma

“…Up to date, several important studies have been performed and a valuable number of approaches have been evaluated for early diagnosis of lung cancer. [ 7 – 18 ] Direct chest radiography and chest computed tomography, which are radiological imaging based techniques, were generally used in these studies. The protocols, with a screening purpose, were established by combining data from radiological imaging with the data obtained from studies performed on materials taken with bronchoscopic techniques.…”

Lung cancer screening with spiral CT

“…In consequence, results from randomized studies remain of critical importance for definitive assessment of the role of lung cancer screening in long-term outcomes. The randomized DANTE trial [29] was designed and started in May 2001 in accordance with these considerations.…”