2020
DOI: 10.1111/jcmm.15688
|View full text |Cite
|
Sign up to set email alerts
|

Danshen (Salvia miltiorrhiza) restricts MD2/TLR4‐MyD88 complex formation and signalling in acute myocardial infarction‐induced heart failure

Abstract: Heart failure (HF) represents a major public health burden. Inflammation has been shown to be a critical factor in the progression of HF, regardless of the aetiology. Disappointingly, the majority of clinical trials targeting aspects of inflammation in patients with HF have been largely negative. Many clinical researches demonstrate that danshen has a good efficacy on HF, and however, whether danshen exerts anti‐inflammatory effects against HF remains unclear. In our study, the employment of a water extracted … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
21
0

Year Published

2021
2021
2023
2023

Publication Types

Select...
8
1

Relationship

1
8

Authors

Journals

citations
Cited by 43 publications
(24 citation statements)
references
References 40 publications
0
21
0
Order By: Relevance
“…Danshen (Salvia Miltiorrhiza) is a very valuable herb in Chinese traditional medicine. It has been reported that Danshen has the antioxidant, antiin ammatory and antibacterial activities 33 . The anti-in ammation e cacy of Danshen is generally played by the main biological activities in it, such as cryptotanshinone, tanshinone IIA and dihydrotanshinone I 34 .…”
Section: Discussionmentioning
confidence: 99%
“…Danshen (Salvia Miltiorrhiza) is a very valuable herb in Chinese traditional medicine. It has been reported that Danshen has the antioxidant, antiin ammatory and antibacterial activities 33 . The anti-in ammation e cacy of Danshen is generally played by the main biological activities in it, such as cryptotanshinone, tanshinone IIA and dihydrotanshinone I 34 .…”
Section: Discussionmentioning
confidence: 99%
“…Rats in the sham group underwent sham surgery, while HF was induced in other rats by direct left anterior descending (LAD) artery ligation as described in our previous study ( Zhang et al, 2018 ). Based on our previous literature ( Zhang et al, 2019 ; Wang et al, 2020a ), 24 h after surgery, the acute myocardial infarction model was established, and the drug treatment was started. Rats in the Cal group were treated with Cal at a dosage of 80 mg/kg per day ( Li et al, 2020 ).…”
Section: Methodsmentioning
confidence: 99%
“…Nuclear factor kappa-B (NFκB) is a crucial heterodimeric transcription factor in inflammatory responses, which is regulated by the IκB kinase (IKK) complex ( Israël, 2010 ). Studies have shown that the persistently activated NFκB pathway in HF progression mediated the excessive release of various inflammatory cytokines such as tumor necrosis factor α (TNFα) and interleukin-1 (IL-1) ( Wang et al, 2020a ). Herein, the IKK-NF-κB pathway is believed to be one of the most attractive targets for HF.…”
Section: Introductionmentioning
confidence: 99%
“…This compound has significantly attenuated cardiac dysfunction and injury induced by isoproterenol and enhanced mitochondrial respiratory function [ 220 ]. In addition, it has shown protective effects against inflammatory injury by modulating forming MD2-TLR4-MyD88 complex and TLR4-TRAF6-NF-κB signaling pathway in acute MI rats [ 221 ]. This compound also suppressed L-type Ca 2+ channels, contraction, and Ca 2+ transients in adult rat cardiac myocytes [ 222 ].…”
Section: Exogenous Natural Antioxidants To Protect Cardiac Muscle From Oxidative Stressmentioning
confidence: 99%