Danofloxacin pharmacokinetics and tissue residues in Bilgorajska geese

Doxycycline pharmacokinetics in geese

“…Further consideration should be made of the following: (1) since in practice doxycycline would typically be given in drinking water, the drug/water intake could differ between animals. It is therefore reasonable to hypothesize that in a practical context the predicted plasma concentration may be lower than that found in the present simulation, with a lower P/T ratio (Sartini et al, 2020(Sartini et al, , 2021. Further, the duration of medicated water availability could affect T>MIC and clinical efficacy; (2) the protein plasma binding of doxycycline in geese is not available in the literature and was not evaluated in the present study.…”

Veterinary pharmacology: A world almost unexplored with huge potential

“…Thus, the support of independent scientists results of paramount importance in order to expand the knowledges even in niche areas of the veterinary field. Recent examples of that have been reported in geese ( Sartini et al., 2020a , 2020 b , 2021a ,2021 b , 2021 c , 2022b ) and crocodiles ( Poapolatep et al., 2017 ; 2020a ,2020 b , 2020 c , 2020 d , 2022a , 2022b) both considered minor species at global level. A long series of drugs have been tested by independent scientists introducing new important data in animals that have been ignored so far.…”

Pharmacokinetic characteristics of danofloxacin in green sea (Chelonia mydas) and hawksbill sea (Eretmochelys imbricata) turtles

“…DNX has a half‐life in cattle of 3 to 6 h, with negligible accumulation. The pharmacokinetics of DNX have been evaluated in mammalians, including calves (Shojaee Aliabadi & Lees, 2003), horses (Fernández‐Varón et al, 2006), sheep (Karademir et al, 2015; Shojaee Aliabadi, Ali, et al, 2003), camels (Shojaee Aliabadi, Landoni, et al, 2003), buffalo calves (Sappal et al, 2009), avians, such as Bilgorajska geese (Sartini et al, 2021), fish, such as trout (Corum et al, 2018) and rainbow trout (Terzi et al, 2020), and reptiles, such as red‐eared slider turtles (Corum et al, 2019) and loggerhead turtles (Marín et al, 2008). The aim of this study was to determine the pharmacokinetics of DNX after a single intravenous (i.v.)…”