Danggui Buxue Tang, a Chinese herbal decoction containing Astragali Radix and Angelicae Sinensis Radix, improves mitochrondial bioenergetics in osteoblast

Kwan, Kenneth Kin Leung; Dong, Tina Ting Xia; Tsim, Karl Wah Keung

doi:10.1016/j.phymed.2021.153605

Cited by 17 publications

(7 citation statements)

References 33 publications

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“…The traditional Chinese medicine compound Danggui Buxue Tang ( Astragalus membranaceus and Angelica sinensis ) has also been shown to increase mitochondrial potential, and cause an increase in mitochondrial length, crista area, total mitochondrial area, area per mitochondrial, and total cell area by approximately 200%, 500%, 180%, and 200%, respectively. It has been shown to regulate mitochondrial function and promote the generation of osteoblasts by influencing mitochondrial morphology and mitochondrial dynamics ( 75 ). Traditional Chinese medicine monomers also play an important role in regulating mitochondrial function.…”

Section: Potential Therapeutic Targeting Of Mitochondria In Osteoporosismentioning

confidence: 99%

Mitochondrial quality control and its role in osteoporosis

et al. 2023

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Mitochondria are important organelles that provide cellular energy and play a vital role in cell differentiation and apoptosis. Osteoporosis is a chronic metabolic bone disease mainly caused by an imbalance in osteoblast and osteoclast activity. Under physiological conditions, mitochondria regulate the balance between osteogenesis and osteoclast activity and maintain bone homeostasis. Under pathological conditions, mitochondrial dysfunction alters this balance; this disruption is important in the pathogenesis of osteoporosis. Because of the role of mitochondrial dysfunction in osteoporosis, mitochondrial function can be targeted therapeutically in osteoporosis-related diseases. This article reviews different aspects of the pathological mechanism of mitochondrial dysfunction in osteoporosis, including mitochondrial fusion and fission, mitochondrial biogenesis, and mitophagy, and highlights targeted therapy of mitochondria in osteoporosis (diabetes induced osteoporosis and postmenopausal osteoporosis) to provide novel targets and prevention strategies for the prevention and treatment of osteoporosis and other chronic bone diseases.

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Section: Potential Therapeutic Targeting Of Mitochondria In Osteoporosismentioning

confidence: 99%

Mitochondrial quality control and its role in osteoporosis

et al. 2023

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“…Bunge (Hedysarum multijugum Maxim, Huangqi), Cimicifugae rhizoma (Largetrifoliolious bugbane rhizome, Shengma), Zingiber officinale Roscoe (Ginger, Shengjiang), and Radix et Rhizoma Glycyrrhizae (Licorice, Gancao). Single herbs in BZYQD, such as Hedysarum multijugum Maxim., Angelicae Sinensis Radix, and Cimicifugae rhizoma , have been reported to have protective effects against OP [ 13 , 14 ]. However, the bioactive compounds and pharmacological mechanism of BZYQD in treating OPF remain unclear and warrant further investigation.…”

Section: Introductionmentioning

confidence: 99%

Deciphering the protective effect of Buzhong Yiqi Decoction on osteoporotic fracture through network pharmacology and experimental validation

Hua

Dai

et al. 2023

J Orthop Surg Res

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Background Osteoporotic fracture (OPF) is one of the most common skeletal diseases in an aging society. The Chinese medicine formula Buzhong Yiqi Decoction (BZYQD) is commonly used for treating OPF. However, the essential bioactive compounds and the underlying molecular mechanisms that promote fracture repair remain unclear. Methods We used network pharmacology and experimental animal validation to address this issue. First, 147 bioactive BZYQD compounds and 32 target genes for treating OPF were screened and assessed. A BZYQD-bioactive compound-target gene-disease network was constructed using the Cytoscape software. Functional enrichment showed that the candidate target genes were enriched in oxidative stress- and inflammation-related biological processes and multiple pathways, including nuclear factor kappa B (NF-κB), and mitogen-activated protein kinase (MAPK) signaling pathways. Furthermore, an OPF rat model was established and treated with BZYQD. Results The results revealed that BZYQD ameliorated OPF characteristics, including femoral microarchitecture, biomechanical properties, and histopathological changes, in a dose-dependent manner. Results of enzyme-linked immunosorbent assay showed that BZYQD reduced the serum’s pro-inflammatory cytokines [Tumor necrosis factor-alpha (TNF-α), Interleukin (IL)-1β, and IL-6] and improved oxidative stress-related factors [glutathione (GSH) and superoxide dismutase (SOD)]. BZYQD significantly decreased the protein expression of NF-κB in OPF rat femurs, suppressed NF-κB activation, and activated the nuclear factor-erythroid factor 2-related factor (Nrf2)/heme oxygenase 1 (HO-1) and p38 MAPK as well ERK pathways. Conclusions Our results suggest that BZYQD could improve inflammation and oxidative stress during fracture repair by suppressing NF-κB and activating Nrf2/MAPK signaling pathways.

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“…DBD is composed of Huangqi ( Radix Astragali ) and Danggui ( Radix Angelicae Sinensis ) in a 5:1 weight ratio, with saponins, flavonoids, and polysaccharides as its major bioactive components [1]. Pharmacological studies have demonstrated that DBD could alleviate pulmonary inflammation to inhibit fibrotic pathology [2], promote follicular development to preserve ovarian function [3], and improve osteoblastic metabolism via mitochondrial bioenergetics [4], etc. The efficacy of DBD may also be affected by gut microbiota, such as Bacteroides, which can impact the metabolism and absorption of active ingredients such as Caffeic acid and Formononetin [5].…”

Section: Introductionmentioning

confidence: 99%

Study on the dynamic metabolic characteristic of main active ingredients in Danggui Buxue Decoction by liquid chromatography‐tandem mass spectrometry based on in situ sequential metabolism strategy

Wang

Gong

Xiao

et al. 2023

J of Separation Science

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Danggui Buxue Decoction is a classic formula for replenishing qi and nourishing blood. Despite its widespread use, its dynamic metabolism involved remains unclear. Based on the sequential metabolism strategy, blood samples from different metabolic sites were obtained via in situ closed intestine ring integrated with a jugular venous continuous blood supply technique. An ultra-high-performance liquid chromatography-linear triple quadruple-Orbitrap-tandem mass spectrometry method was developed for the identification of prototypes and metabolites in rat plasma. The dynamic absorption and metabolic landscape of flavonoids, saponins, and phthalides were characterized. Flavonoids could be deglycosylated, deacetylated, demethylated, dehydroxylated, and glucuronicated in the gut and then absorbed for further metabolism. Jejunum is an important metabolic site for saponins biotransformation. Saponins that are substituted by Acetyl groups tend to lose their acetyl groups and convert to Astragaloside IV in the jejunum. Phthalides could be hydroxylated and glucuronidated in the gut and then absorbed for further metabolism. Seven components serve as crucial joints in the metabolic network and are potential candidates for the quality control of Danggui Buxue Decoction. The sequential metabolism strategy described in this study could be useful for characterizing the metabolic pathways of Chinese medicine and natural products in the digestive system.

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Danggui Buxue Tang, a Chinese herbal decoction containing Astragali Radix and Angelicae Sinensis Radix, improves mitochrondial bioenergetics in osteoblast

Cited by 17 publications

References 33 publications

Mitochondrial quality control and its role in osteoporosis

Mitochondrial quality control and its role in osteoporosis

Deciphering the protective effect of Buzhong Yiqi Decoction on osteoporotic fracture through network pharmacology and experimental validation

Study on the dynamic metabolic characteristic of main active ingredients in Danggui Buxue Decoction by liquid chromatography‐tandem mass spectrometry based on in situ sequential metabolism strategy

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