Dangerous versus useful hypertension (A holistic view of hypertension)

Hulín, I; Duris, I; Paulis, Ludovít; Sapáková, E; Mravec, Boris

doi:10.1016/j.ejim.2008.07.009

Cited by 3 publications

(2 citation statements)

References 14 publications

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“…Secondary HTN has identifiable pathological cause such as (a) hyperaldosteronism (b) renal artery stenosis, (c) phaeochromocytoma, (d) preeclamptic toxaemia (Levick, 2003). Sadly, HTN in childhood has now been recognized as a common and serious problem, with a prevalence of between 2% to 5% (Kavey et al, 2010 (Williams, 2008;Hulin et al, 2009). In rats, BP below 125/83 mm Hg is considered to be normal, while a SBP above 140 mm Hg is generally considered to be HTN (Anderson et al, 2006;Charles River Laboratories International, 2009).…”

Section: Hypertensionmentioning

confidence: 99%

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Effect of Tulbaghia violacea on the blood pressure and heart rate in male spontaneously hypertensive Wistar rats

Raji

Mugabo

Obikeze

2012

Journal of Ethnopharmacology

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Effect of Tulbaghia violacea on the blood pressure and heart rate in male spontaneously hypertensive Wistar rats I. A. RAJITulbaghia violacea Harv. (Alliaceae) is a small bulbous herb which belongs to the family, Alliaceae, most commonly associated with onions and garlic. In South Africa (SA), this herb has been traditionally used in the treatment of various ailments, including fever, colds, asthma, paralysis, hypertension (HTN) and stomach problems. The aim of this study was to evaluate the effect of methanol leaf extracts (MLE) of T. violacea on the blood pressure (BP) and heart rate (HR) in anaesthetized male spontaneously hypertensive rats; and to find out the mechanism(s) by which it acts.The MLE of T. violacea (5 -150 mg/kg), angiotensin I (ang I, 3.1 -100 µg/kg), captopril (10 mg/kg), angiotensin II (ang II, 3.1 -50 µg/kg), losartan (30 mg/kg), phenylephrine T. violacea (60 mg/kg) and captopril (10 mg/kg) were injected intraperitoneally into iii some SHR for 21 days to investigate the chronic effect of these agents on plasma levels of aldosterone. The mean change, the mean of the individual percentage changes and the percentage difference (in mean) observed with each intervention was calculated and statistically analyzed using the Student's t test for significant difference (p < 0.05). The Microsoft Excel software was used for statistical analysis.T. violacea significantly (p < 0.05) reduced the systolic, diastolic, and mean arterial BP;and HR dose-dependently. In a dose-dependent manner, ang I, ang II, phenylephrine significantly (p < 0.05) increased the BP, while propranolol, muscarine and atropine reduced the BP. The increases in BP due to dobutamine were not dose-dependent. In a dose dependent manner, phenylephrine and propranolol reduced the HR, while dobutamine increased the HR. The effect of ang I, ang II, muscarine and atropine on HR were not dose-dependent; with both increases as well as decreases observed with ang I, and II and atropine, while decreases were seen with muscarine. Captopril produced significant (p < 0.05) reduction in BP which were not associated with any change in HR.The co-infusion of ang I with the MLE produced significant (p < 0.05) reduction in BP, which were not associated with significant changes in HR. The co-infusion of ang II with the MLE did not produce any significant changes in BP or HR when compared to the infusion of the standard drug alone. The co-infusion of phenylephrine with the MLE did

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Section: Hypertensionmentioning

confidence: 99%

“…Luminal diameter can be altered actively by the contraction of smooth muscles, or passively by remodelling; under the influences of the hemodynamic load, neuro-humoral regulation and the concentrations of sodium and potassium ions (Hulin et al, 2009). The product of the TPR and CO gives the arterial BP (Levick, 2003).…”

Section: The Peripheral Vascular Resistancementioning

confidence: 99%

Effect of Tulbaghia violacea on the blood pressure and heart rate in male spontaneously hypertensive Wistar rats

Raji

Mugabo

Obikeze

2012

Journal of Ethnopharmacology

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Genetics and Pathophysiology of Essential Hypertension

Khullar¹

2012

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users to download, copy and build upon published articles even for commercial purposes, as long as the author and publisher are properly credited, which ensures maximum dissemination and a wider impact of our publications. After this work has been published by InTech, authors have the right to republish it, in whole or part, in any publication of which they are the author, and to make other personal use of the work. Any republication, referencing or personal use of the work must explicitly identify the original source.As for readers, this license allows users to download, copy and build upon published chapters even for commercial purposes, as long as the author and publisher are properly credited, which ensures maximum dissemination and a wider impact of our publications. NoticeStatements and opinions expressed in the chapters are these of the individual contributors and not necessarily those of the editors or publisher. No responsibility is accepted for the accuracy of information contained in the published chapters. The publisher assumes no responsibility for any damage or injury to persons or property arising out of the use of any materials, instructions, methods or ideas contained in the book.

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Harmful or Helpful Hypertension – Pathophysiological Basis

Budaj¹,

Hulín²

2012

Genetics and Pathophysiology of Essential Hypertension

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Dangerous versus useful hypertension (A holistic view of hypertension)

Cited by 3 publications

References 14 publications

Effect of Tulbaghia violacea on the blood pressure and heart rate in male spontaneously hypertensive Wistar rats

Effect of Tulbaghia violacea on the blood pressure and heart rate in male spontaneously hypertensive Wistar rats

Genetics and Pathophysiology of Essential Hypertension

Harmful or Helpful Hypertension – Pathophysiological Basis

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