Dangerous Disappearing Act: Commensal Gut Microbiota After Acute Severe Insults

Alcock, Joe

doi:10.1007/s10620-011-1698-7

Cited by 2 publications

(1 citation statement)

References 20 publications

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“…On the other side, both can render the diseases more severe and may be lethal. [ 5 ] The environment, the host, and the presence of other ailments are amid the contributing factors that modulate the microbiota composition. [ 6 ] Disturbed community of intestinal microbiota (dysbiosis) has been reported to have a link to multiple chronic diseases including autoimmune disorders and various psychiatric disorders like depression.…”

Section: Introductionmentioning

confidence: 99%

Work stress, dysbiosis, and immune dysregulation: The interconnected triad in COVID-19 infection in the medical team staff – A mini-review

Yousof

Tanvir

Kolieb

et al. 2022

J Microsc Ultrastruct

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The COVID-19 pandemic has hit most of the communities around the globe. Earlier researches have reported the psychological effects of pandemics either on the general populations or on specific communities such as students and health professionals. A scanty number of papers have focused on the interaction among complex factors underlying the pathogenesis of the disease. In this review, we aimed to integrate the accessible data about the possible mechanistic processes predisposing to COVID-19 infection in the health professions. We summarized these factors as “stress, microbiota, and immunity triad.” We utilized the PubMed database, Google, and Google Scholar search engines to search the literature related to combinations of these keywords: “pandemics, COVID-19, coronavirus, SARS-CoV2;” “gut microbiota, gut-lung axis, dysbiosis, nutrition;” “work stress, workload, health workers, health professions, and medical team;” and “immunity, cytokine storm, and viral load.” We detected no discussions combining the suggested triad concerning the medical team personnel. We cast light, for the first time to our knowledge, on the potential pathogenic role of “stress, microbiota, and immunity triad” in COVID-19-infected health workers.

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Section: Introductionmentioning

confidence: 99%

Work stress, dysbiosis, and immune dysregulation: The interconnected triad in COVID-19 infection in the medical team staff – A mini-review

Yousof

Tanvir

Kolieb

et al. 2022

J Microsc Ultrastruct

View full text Add to dashboard Cite

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The gut microbiota and gastrointestinal surgery

Guyton

Alverdy

2016

Nat Rev Gastroenterol Hepatol

152

138

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Surgery involving the gastrointestinal tract continues to prove challenging because of the persistence of unpredictable complications such as anastomotic leakage and life-threatening infections. Removal of diseased intestinal segments results in substantial catabolic stress and might require complex reconstructive surgery to maintain the functional continuity of the intestinal tract. As gastrointestinal surgery necessarily involves a breach of an epithelial barrier colonized by microorganisms, preoperative intestinal antisepsis is used to reduce infection-related complications. The current approach to intestinal antisepsis varies widely across institutions and countries with little understanding of its mechanism of action, effect on the gut microbiota and overall efficacy. Many of the current approaches to intestinal antisepsis before gastrointestinal surgery run counter to emerging concepts of intestinal microbiota contributing to immune function and recovery from injury. Here, we review evidence outlining the role of gut microbiota in recovery from gastrointestinal surgery, particularly in the development of infections and anastomotic leak. To make surgery safer and further reduce complications, a molecular, genetic and functional understanding of the response of the gastrointestinal tract to alterations in its microbiota is needed. Methods can then be developed to preserve the health-promoting functions of the microbiota while at the same time suppressing their harmful effects.

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Dangerous Disappearing Act: Commensal Gut Microbiota After Acute Severe Insults

Cited by 2 publications

References 20 publications

Work stress, dysbiosis, and immune dysregulation: The interconnected triad in COVID-19 infection in the medical team staff – A mini-review

Work stress, dysbiosis, and immune dysregulation: The interconnected triad in COVID-19 infection in the medical team staff – A mini-review

The gut microbiota and gastrointestinal surgery

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