Danger signals in liver injury and restoration of homeostasis

Han, Hui; Désert, Romain; Das, Subodh K.; Song, Zhuolun; Athavale, Dipti; Ge, Xiaodong; Nieto, Natalia

doi:10.1016/j.jhep.2020.04.033

Cited by 53 publications

(43 citation statements)

References 270 publications

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“…Hepatocellular carcinoma is a dominating histological subtype (about 90%) of primary liver cancer and the second most prevalent cause of cancer-related deaths in China (Chen et al, 2016;Forner et al, 2018). HCC commonly occurs under the conditions of hepatitis B/C (HBV/HCV)-mediated chronic inflammation and metabolic syndrome (Han et al, 2020;McGlynn et al, 2020). Currently, only one third of cases are eligible for curative treatments, and the therapeutic strategies for advanced HCC are limited, which leads to the poor prognosis of patients (Gunasekaran et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Hypoxia-Inducible Ubiquitin Specific Peptidase 13 Contributes to Tumor Growth and Metastasis via Enhancing the Toll-Like Receptor 4/Myeloid Differentiation Primary Response Gene 88/Nuclear Factor-κB Pathway in Hepatocellular Carcinoma

Gao

Chen

et al. 2020

Front. Cell Dev. Biol.

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Section: Introductionmentioning

confidence: 99%

Hypoxia-Inducible Ubiquitin Specific Peptidase 13 Contributes to Tumor Growth and Metastasis via Enhancing the Toll-Like Receptor 4/Myeloid Differentiation Primary Response Gene 88/Nuclear Factor-κB Pathway in Hepatocellular Carcinoma

Gao

Chen

et al. 2020

Front. Cell Dev. Biol.

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“…Oxidative stress induced by excessive ROS production led to the dysfunction of hepatic homeostasis, which triggered liver injury, manifesting as an inflammation response, lipid peroxidation, DNA damage, and cell apoptosis, resulting in several chronic liver diseases [ 15 , 23 ]. As the results demonstrate, L02 cells treated with H 2 O 2 , causing a significant rise in ROS levels, suffered from cell death and morphological changes.…”

Section: Resultsmentioning

confidence: 99%

“…On the other hand, the available evidence has shown that inflammation, an imperative physiological reaction, plays an important role in the occurrence and development of many diseases, and during the pathological process, the inflammatory response could be activated by oxidative stress [ 22 , 23 , 24 ]. COX-2, a potent enzyme induced by cytokines, mitogens or endotoxins, can initiate inflammation and promote the synthesis of prostaglandins, which exert pro-inflammatory effects.…”

Section: Introductionmentioning

confidence: 99%

“…COX-2, a potent enzyme induced by cytokines, mitogens or endotoxins, can initiate inflammation and promote the synthesis of prostaglandins, which exert pro-inflammatory effects. More recently, emerging research has shown that COX-2 expression is altered in many liver related diseases, such as NAFLD, liver fibrosis and hepatocellular carcinoma, which causes the progression of hepatocellular injury, including inflammation, autophagy and cell senescence [ 23 , 25 ]. These studies have proposed a possible adjunctive treatment strategy targeting COX-2 for liver diseases.…”

Section: Introductionmentioning

confidence: 99%

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Phenolic Compounds from Carissa spinarum Are Characterized by Their Antioxidant, Anti-Inflammatory and Hepatoprotective Activities

et al. 2021

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Carissa spinarum has been traditionally used for the treatment of various diseases due to its different pharmacological activities. However, the active compounds responsible for its potentially specific activities have rarely been explored. To this end, the ethyl acetate (EA) fraction was screened out and selected for further phytochemical isolation because of its promising activities in preliminary 2,2-diphenyl-1-picrylhydrazyl (DPPH), ferric reducing antioxidant power (FRAP) and COX-2 inhibition assays. As a result, 10 compounds (1−10), including a new one (5), were isolated, with eight of these being identified as phenolic compounds, as expected. Compound 9 possessed an IC50 value of 16.5 ± 1.2 µM, which was lower than that of positive control (vitamin C, 25.5 ± 0.3 µM) in the DPPH assay, and compounds 2, 6, 7 and 9 showed better total antioxidant capacity than vitamin C in the FRAP assay. Meanwhile, compounds 1−6 and 9 also had IC50 values of less than 1.0 µM, which was even better than the positive control indomethacin in the COX-2 inhibition assay. In this context, compounds 2 and 9 were further evaluated to exhibit clear hepatoprotective activities by improving the L02 cell viability and reducing ROS production using a H2O2-induced L02 cell injury model. This study provides initial evidence revealing the most potent phenolic compounds from the root bark of C. spinarum responsible for its antioxidant, anti-inflammatory and hepatoprotective activities.

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“…Moreover, long‐term excessive drinking causes the body to produce excessive oxygen free radicals to be consumed timely by antioxidants, thereby resulting in the imbalance between oxidation and antioxidant in the body. Subsequently, the body's antioxidant defense system is destroyed (Dunn & Shah, 2016; Han et al, 2020). Some biological macromolecules, such as nucleic acid and protein, are oxidized by excessive ROS (Lee, Gupta, Bang, Bae, & Sung, 2013), which can damage cell membrane and accelerate cell apoptosis (Louvet & Mathurin, 2015; Yang & Lian, 2020).…”

Section: Introductionmentioning

confidence: 99%

Reactive oxygen species‐responsive silk sericin microcapsules used for antioxidative stress damage

Wang

Sun

et al. 2020

Microscopy Res & Technique

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Silk sericin microcapsules loaded with horseradish peroxidase (HRP) are prepared through protein self-assembly in a green environment containing enzymes to protect liver cells from alcohol damage. Load content and release dynamics of HRP in sericin microcapsules are investigated. The role of HRP-loaded microcapsules in hydrogen peroxide (H 2 O 2) degradation is demonstrated using electrochemical method. Furthermore, the effect of the HRP-loaded microcapsules on cells and intracellular reactive oxygen species (ROS) level is evaluated using an alcohol damage model in vitro. Results show that HRP can be loaded effectively in the sericin microcapsules and can be released ROS-responsively from microcapsules. Cell survival rate increases after suffering from alcohol damage due to the presence of HRP-loaded microcapsule, and the active oxygen content in cells is maintained at a stable level even when it remained in an environment with high alcohol concentration. We believe that the internalized sericin microcapsules maintain HRP activity intracellularly, allow controlled HRP release within a host cell, and show excellent ability in antioxidative stress injury.

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Danger signals in liver injury and restoration of homeostasis

Cited by 53 publications

References 270 publications

Hypoxia-Inducible Ubiquitin Specific Peptidase 13 Contributes to Tumor Growth and Metastasis via Enhancing the Toll-Like Receptor 4/Myeloid Differentiation Primary Response Gene 88/Nuclear Factor-κB Pathway in Hepatocellular Carcinoma

Hypoxia-Inducible Ubiquitin Specific Peptidase 13 Contributes to Tumor Growth and Metastasis via Enhancing the Toll-Like Receptor 4/Myeloid Differentiation Primary Response Gene 88/Nuclear Factor-κB Pathway in Hepatocellular Carcinoma

Phenolic Compounds from Carissa spinarum Are Characterized by Their Antioxidant, Anti-Inflammatory and Hepatoprotective Activities

Reactive oxygen species‐responsive silk sericin microcapsules used for antioxidative stress damage

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