2019
DOI: 10.3389/fmed.2019.00221
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Danger of Herbal Tea: A Case of Acute Cholestatic Hepatitis Due to Artemisia annua Tea

Abstract: Background: Artemisia annua is a Chinese medicinal herb. Artemisinin-derivatives are recommended as part of a combination treatment for uncomplicated malaria. Herbal and dietary supplements (HDS) are increasingly used worldwide and HDS-induced liver injury is becoming a growing concern.Case Report: We present the first case of severe acute cholestatic hepatitis due to the intake of Artemisia annua tea as chemoprophylaxis for malaria in a patient returning from Ethiopia. The patients presented with jaundice, el… Show more

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Cited by 16 publications
(13 citation statements)
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References 21 publications
(24 reference statements)
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“…The mass spectra (Figure 2) showed the presence of complex metabolite composition. A total of 103 compounds were detected and identified, which covered various chemical categories, including amino acids, sterols, terpenoids, flavonoids, coumarins, alcohols, aldehydes, glycosides, carbohydrates, fatty acids and so on, which confirmed the data reported in the literature [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24]28,[31][32][33][34][35][36][37][38][39]46,[53][54][55][56][57][58][59][60]. Additionally, the presence of amino acids identified through GC-MS was confirmed via ESI-QTOF-MS The results are listed in Table 1, which presents tentative amino acid identification via GC-MS corresponding to Artemisia annua sample [32,54,55].…”
Section: Mass Spectrometry Analysis Of Romanian Artemisia Annuasupporting
confidence: 73%
See 1 more Smart Citation
“…The mass spectra (Figure 2) showed the presence of complex metabolite composition. A total of 103 compounds were detected and identified, which covered various chemical categories, including amino acids, sterols, terpenoids, flavonoids, coumarins, alcohols, aldehydes, glycosides, carbohydrates, fatty acids and so on, which confirmed the data reported in the literature [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24]28,[31][32][33][34][35][36][37][38][39]46,[53][54][55][56][57][58][59][60]. Additionally, the presence of amino acids identified through GC-MS was confirmed via ESI-QTOF-MS The results are listed in Table 1, which presents tentative amino acid identification via GC-MS corresponding to Artemisia annua sample [32,54,55].…”
Section: Mass Spectrometry Analysis Of Romanian Artemisia Annuasupporting
confidence: 73%
“…Recently, several cases of liver disease have been reported, especially following selfmedication with herbal supplements to manage cancer or prevent malaria [38,39].…”
Section: Introductionmentioning
confidence: 99%
“…With 11,609 the largest HILI case number was published in 2019 ( Figure 3 ) as a consequence of the ongoing worldwide use of RUCAM for assessing causality in suspected HILI cases ( Table 4 ). In particular, contributing countries were in alphabetical order Australia [ 29 ], Brazil [ 183 ], China [ 48 , 196 , 197 , 198 , 199 , 200 , 201 ], Germany [ 213 , 214 , 215 ], India [ 217 ], Italy [ 222 ], Korea [ 103 ], Spain [ 115 , 117 , 240 , 241 , 242 ], Switzerland [ 244 ], and the US [ 245 , 246 , 247 , 248 , 249 , 250 , 251 , 252 , 253 , 254 ]. Most of the 11,619 HILI cases published in 2019 were from China [ 48 , 196 ] and Korea [ 103 ], with 6971 cases published by Shen et al [ 48 ], 2019 cases reported by Byeon et al [ 103 ], and 1552 cases provided by Chow et al [ 196 ].…”
Section: Worldwide Publications Of Hili Cases Assessed For Causalimentioning
confidence: 99%
“…Lobular inflammation ( 5 ) and lymphocytic infiltration of the bile ducts ( 6 ) have been found on live biopsy.…”
Section: Discussionmentioning
confidence: 99%