DAN directs endolymphatic sac and duct outgrowth in the avian inner ear

Gerlach-Bank, Lisa M.; Cleveland, Amanda R.; Barald, Kate F.

doi:10.1002/dvdy.10414

Cited by 27 publications

(36 citation statements)

References 32 publications

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“…6a) which is supposed to bind BMP ligands . Vertebrate DAN was identified as an antitumorigenic factor (Enomoto et al 1994) and plays, among other functions, a role in ear development (Gerlach-Bank et al 2004;Yamanishi et al 2007). A DAN ortholog is found in the Apis genome as well (Fig.…”

Section: Modulators Of Tgfb Signalingmentioning

confidence: 96%

TGFβ signaling in Tribolium: vertebrate-like components in a beetle

2008

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The cytokines of the TGFbeta superfamily are highly conserved in evolution and elicit a diverse range of cellular responses in all metazoa. In Drosophila, the signaling pathways of the two TGFbeta subfamilies, Activins and Bone Morphogenetic Proteins (BMPs), have been well studied. To address the question of whether the findings from Drosophila are representative of insects in general, we analyzed the components of TGFbeta-signaling present in the genome of the beetle Tribolium castaneum. We were able to identify orthologs of the BMPs Decapentaplegic and Glass bottom boat, of the Activins Activinbeta and Dawdle, as well as orthologs of the less well-known ligands Myoglianin and Maverick, together with orthologs of all TGFbeta receptors and cytoplasmic signal transducers present in Drosophila. This indicates that the diversity of TGFbeta signaling components is generally well conserved between Drosophila and Tribolium. However, the genome of the beetle-and of the bee Apis mellifera-lacks an ortholog of the Drosophila BMP Screw but does contain a vertebrate-like BMP10 homolog which is not found in Drosophila. Concerning BMP inhibitors, Tribolium displays an even more vertebrate-like ensemble of components. We found two orthologs of the vertebrate DAN family, Dan and Gremlin, and show embryonic expression of a vertebrate-like BAMBI ortholog, all of which are absent in Drosophila. This suggests that Tribolium might have retained a more ancestral composition of TGFbeta signaling components and that TGFbeta signaling underwent considerable change in the Drosophila lineage. Tribolium is an excellent model to study the function of these ancestral signaling components in insects.

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Section: Modulators Of Tgfb Signalingmentioning

confidence: 96%

TGFβ signaling in Tribolium: vertebrate-like components in a beetle

2008

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“…The size of the ED is also affected by other proteins, notably Dan (differential screening-selected genes aberrative in neuroblastoma) (Gerlach-Bank et al, 2004) and Six1, which are both discussed later.…”

Section: Fox Genesmentioning

confidence: 99%

From placode to polarization: new tunes in inner ear development

2004

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The highly orchestrated processes that generate the vertebrate inner ear from the otic placode provide an excellent and circumscribed testing ground for fundamental cellular and molecular mechanisms of development. The recent pace of discovery in developmental auditory biology has been unusually rapid,with hundreds of papers published in the past 4 years. This review summarizes studies addressing several key issues that shape our current thinking about inner ear development, with particular emphasis on early patterning events,sensory hair cell specification and planar cell polarity.

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“…Specifically, BMPs and their antagonists are involved in establishing the anteroposterior and dorsoventral axes of the inner ear (Chang et al, 1999;Gerlach et al, 2000). In addition, local application of either the BMP antagonists noggin or DAN, or retinoic acid (which represses Bmp4 transcription) to chick embryo otocysts impairs development of the semicircular canals, whereas simultaneous exposure to recombinant BMP4 rescues semicircular canal development (Chang et al 1999;Gerlach et al, 2000;Thompson et al, 2003;Gerlach-Bank et al, 2004;Barald and Kelley, 2004). Li et al, 2005, used a chick otocyst culture system to demonstrate that both hair cell and supporting cell numbers were significantly reduced when BMP4 signaling was blocked.…”

Section: Introductionmentioning

confidence: 99%

The role of bone morphogenetic protein 4 in inner ear development and function

Blauwkamp

Beyer²,

Kabara³

et al. 2007

Hearing Research

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Bone Morphogenetic Protein 4 (BMP4) is a member of the TGF-β superfamily and is known to be important for the normal development of many tissues and organs, including the inner ear. Bmp4 homozygous null mice die as embryos, but Bmp4 heterozygous null (Bmp4 +/− ) mice are viable and some adults exhibit a circling phenotype, suggestive of an inner ear defect. To understand the role of BMP4 in inner ear development and function, we have begun to study C57BL/6 Bmp4 +/− mice. Quantitative testing of the vestibulo-collic reflex, which helps maintain head stability, demonstrated that Bmp4 +/− mice that exhibit circling behavior have a poor response in the yaw axis, consistent with semicircular canal dysfunction. Although the hair cells of the ampullae were grossly normal, the stereocilia were greatly reduced in number. Auditory brainstem responses showed that Bmp4 +/− mice have elevated hearing thresholds and immunohistochemical staining demonstrated decreased numbers of neuronal processes in the organ of Corti. Thus Bmp4 +/− mice have structural and functional deficits in the inner ear.

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DAN directs endolymphatic sac and duct outgrowth in the avian inner ear

Cited by 27 publications

References 32 publications

TGFβ signaling in Tribolium: vertebrate-like components in a beetle

TGFβ signaling in Tribolium: vertebrate-like components in a beetle

From placode to polarization: new tunes in inner ear development

The role of bone morphogenetic protein 4 in inner ear development and function

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