Damping Force and Loading Position Dependence of Mass Sensitivity of Magnetoelastic Biosensors in Viscous Liquid

Abstract

We established the vibration governing equation for a magnetoelastic (ME) biosensor with target loading in liquid. Based on the equation, a numerical simulation approach was used to determine the effect of the target loading position and viscous damping coefficient on the node (“blind points”) and mass sensitivity (Sm) of an ME biosensor under different order resonances. The results indicate that viscous damping force causes the specific nodes shift but does not affect the overall variation trend of Sm as the change of target loading position and the effect on Sm gradually reduces when the target approaches to the node. In addition, Sm decreases with the increase of viscous damping coefficient but the tendency becomes weak at high-order resonance. Moreover, the effect of target loading position on Sm decreases with the increase of viscous damping coefficient. Finally, the results provide certain guidance on improving the mass sensitivity of an ME biosensor in liquid by controlling the target loading position.

Magnetoelastic Resonance Sensors: Principles, Applications, and Perspectives

“…In a similar way, Zhang et al analyzed the influence of the mass loading position and resonance mode on the mass sensitivity in a liquid medium, with the aim of investigating the effect of the viscous damping coefficient on the sensitivity. 108 It was found that sensitivity decreases with the increase of the viscous damping coefficient, but this tendency became weaker at higher resonance modes. All these results indicated the clear advantages of ME sensors which, unlike other AW sensors, could overcome the blind point issue by operating under both odd and even modes, which is the direct benefit of its freestanding nature.…”

“…They confirmed that a mass load on the resonator center does not affect the frequency when measuring in the first resonance mode, while the frequency shift was maximum at this point when measuring in the second resonance mode and so on. In a similar way, Zhang et al analyzed the influence of the mass loading position and resonance mode on the mass sensitivity in a liquid medium, with the aim of investigating the effect of the viscous damping coefficient on the sensitivity . It was found that sensitivity decreases with the increase of the viscous damping coefficient, but this tendency became weaker at higher resonance modes.…”

Role of extrinsic factors on magnetoelastic resonance biosensors sensitivity

“…Saiz et al [4] summarized three critical parameters for enhancing the performance of ME sensors, namely: (I) sensitivity and the minimum detection limit, (II) resonance quality factor, and (III) sensor corrosion resistance. Numerous studies have explored ways to increase sensitivity, focusing on reducing sensor size [19], altering geometry [20], and optimizing mass positioning [21,22]. However, external interferences can significantly impact the resonance response of ME biosensors and reduce sensitivity.…”

Fabricated electromechanical resonator sensor for liquid viscosity measurement

“…In medicine, changes in blood viscosity are also symptoms of high blood pressure and heart diseases [2][3][4]. It has been reported in many works that a liquid has a strong damping effect on the resonator sensor [5][6][7][8][9]. In other words, different damping coefficients of fluids affect mechanical displacement of the resonators.…”