Abstract:Most organisms have
circadian clocks to ensure the metabolic cycle
to resonate with the rhythmic environmental changes without “damping,”
or losing robustness. Cyanobacteria is the oldest and simplest form
of life that is known to harbor this biological intricacy. Its KaiABC-based
central oscillator proteins can be reconstituted inside a test tube,
and the post-translational modification cycle occurs with 24 h periodicity.
KaiC’s two major phosphorylation sites, Ser-431 and Thr-432,
become phosphorylated and d… Show more
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