Damage to the Immature Optic Radiation Causes Severe Reduction of the Retinal Nerve Fiber Layer, Resulting in Predictable Visual Field Defects

Abstract

Primary injuries in the immature OR are associated with reduced RNFL thickness, and examination of the RNFL may be a helpful predictor of VF defects.

Fetal brain lesions after subcutaneous inoculation of Zika virus in a pregnant nonhuman primate

“…The distribution of white matter injury is predicted to result in visual field loss (injury to optic tracts) and neurodevelopmental delay. 12 A similar, but more severe pattern of white matter injury with involvement of the occipital horns of the lateral ventricle also was seen in a Brazilian child with congenital ZIKV syndrome (Fig. S8).…”

Retinal Sequelae in Adults Treated With Cryotherapy for Retinopathy of Prematurity

“…Recently, an extreme relationship was demonstrated in a group of ex-preterms without history of ROP treatment but suffering from white matter damage of immaturity. 18 In that study, the RNFL was predicted by the damage to the optic radiation. The appearance of the RNFL structure in our study group is more likely be explained by the history of severe ROP.…”

Retinal structure assessed by OCT as a biomarker of brain development in children born small for gestational age

“…Primary injuries in immature optic radiation are frequently associated with structural changes in the retina. Lennartsson et al 25 performed brain MRI and OCT in seven cases of young adults born preterm with known white matter damage due to immaturity and concluded that RNFL loss was more pronounced in subjects with more extensive lesions, following the pattern of the optic radiation damage. We propose a double mechanism for neuronal changes in the retina of children born SGA.…”