Damage to the human lumbar cartilage endplate and its clinical implications

Huang, Bao; Liu, Junhui; Wei, Xiaoan; Li, Shengwen; Xiang, Yufeng; Wu, Hao; Chen, Jian; Zhao, Fengdong

doi:10.1111/joa.13321

Cited by 21 publications

(20 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…36 Calcification is considered the hallmark of CEP degeneration, and the NP has been shown to be the primary area affected by CEP degeneration. 37 However, MRI of the CEP is challenging due to its physiological thickness of only approximately 0.6 mm; and ultrashort echo time (UTE) imaging is considered a promising technique. 38 Kim et al reported that three-dimensional UTE MRI could be used to depict CEP and CEP abnormalities, which might be associated with the severity of disk degeneration on T2-weighted spin-echo MRI.…”

Section: Discussionmentioning

confidence: 99%

“…It has been reported that when osteoporosis leads to changes in the microenvironment of the vertebral body, the morphology of the CEPs of the vertebral body is first altered, which in turn causes nutritional disorders and degeneration of the IVD 36 . Calcification is considered the hallmark of CEP degeneration, and the NP has been shown to be the primary area affected by CEP degeneration 37 . However, MRI of the CEP is challenging due to its physiological thickness of only approximately 0.6 mm; and ultrashort echo time (UTE) imaging is considered a promising technique 38 .…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Q‐Dixon and GRAPPATINI T2 Mapping Parameters: A Whole Spinal Assessment of the Relationship Between Osteoporosis and Intervertebral Disc Degeneration

Xie

Lü

et al. 2021

Magnetic Resonance Imaging

View full text Add to dashboard Cite

Background The relationship between osteoporosis and intervertebral disc (IVD) degeneration remains controversial. Novel quantitative Dixon (Q‐Dixon) and GRAPPATINI T2 mapping techniques have shown potential for evaluating the biochemical components of the spine. Purpose To investigate the correlation of osteoporosis with IVD degeneration in postmenopausal women. Study Type Prospective. Subjects A total of 105 postmenopausal females (mean age, 65 years; mean body mass index, 26 kg/m2). Field Strength/Sequence 3 T; sagittal; 6‐echo Q‐Dixon, multiecho spin‐echo GRAPPATINI T2 mapping, turbo spin echo (TSE) T1‐weighted and TSE T2‐weighted sequences. Assessment The subjects were divided into normal (N = 47), osteopenia (N = 28), and osteoporosis (N = 30) groups according to quantitative computed tomography examination. The Pfirrmann grade of each IVD was obtained. Region of interest analysis was performed separately by two radiologists (X.L., with 10 years of experience, and S.C., with 20 years of experience) on a fat fraction map and T2 map to calculate the bone marrow fat fraction (BMFF) from the L1 to L5 vertebrae and the T2 values of each adjacent IVD separately. Statistical Tests One‐way analysis of variance, post‐hoc comparisons, and Kruskal–Wallis H tests were performed to evaluate the differences in the magnetic resonance imaging parameters between the groups. The relationships between BMFF and the IVD features were analyzed using the Spearman correlation analysis and linear regression models. Results There were significant differences in BMFF among the three groups. The osteoporosis group had higher BMFF values (64.5 ± 5.9%). No significant correlation was found between BMFF and Pfirrmann grade (r = 0.251, P = 0.06). BMFF was significantly negatively correlated with the T2 of the adjacent IVD from L1 to L3 (r = −0.731; r = −0.637; r = −0.547), while significant weak correlations were found at the L4 to L5 levels (r = −0.337; r = −0.278). Data Conclusion This study demonstrated that osteoporosis is associated with IVD degeneration. Level of Evidence 2 Technical Efficacy Stage 4

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Q‐Dixon and GRAPPATINI T2 Mapping Parameters: A Whole Spinal Assessment of the Relationship Between Osteoporosis and Intervertebral Disc Degeneration

Xie

Lü

et al. 2021

Magnetic Resonance Imaging

View full text Add to dashboard Cite

show abstract

“…We speculated that the main reasons leading to the low short‐term fusion rate in patients with MCs might be inflammatory factors and a reduced blood supply in the fusion area. Inflammatory factors such as TNF‐α can be produced in the intervertebral space by low‐toxicity infection of the intervertebral space, autoimmune reactions caused by exposure to the nucleus pulposus and intraoperative curettage of the endplate cartilage 24,25 . TNF‐α inhibits the osteogenic differentiation of mesenchymal stem cells by activating the NF‐κB pathway or Notch receptors, 7,26 which may lead to trabecular bone formation between the implanted bone and vertebral bone.…”

Section: Discussionmentioning

confidence: 99%

Does Preoperative Modic Changes Influence the Short‐term Fusion Rate of Single Level Transforaminal Lumbar Interbody Fusion?—a Matched‐pair Case Control Study

Xiao

Peng

Yang

et al. 2023

Orthopaedic Surgery

View full text Add to dashboard Cite

ObjectiveAt present, the influence of Modic changes (MCs) on postoperative fusion rate of lumbar interbody fusion (LIF) is mainly focused on the medium‐ and long‐term fusion rate, while the short‐term fusion rate has not been reported. The aim of this study was to compare the short‐term fusion rate of lumbar degenerative disease patients with and without MCs after single level transforaminal lumbar interbody fusion (TLIF).MethodsIn this retrospective and matched‐pair case control study, we included 100 patients who underwent TLIF from January 2017 to January 2020 and had at least two follow‐up visits over a two‐year period. Fifty patients with MCs (MCs group) were matched with 50 patients without MCs (non MCs group) for age, sex, surgical level, diagnosis, operative time, and intraoperative blood loss. We collected the X‐ray and computed tomography (CT) data of patients from 3 months to 2 years after the operation to assess bony fusion and the cage union ratio. According to the type of cage, the MCs group was further divided into the nano‐hydroxyapatite/polyamide 66 (n‐HA/PA66) group and polyetheretherketone (PEEK) group, and the fusion performance between the two groups was compared. Finally, age, sex, body mass index (BMI), smoking and cage type were included in the logistic regression model for risk factor analysis.ResultsThe bony fusion rates in the MCs group at 3 months, 6 months, 1 year and 2 years after surgery were significantly lower than those in the non MCs group (P < 0.05) (23.8% vs 62.5%, 52.6% vs 78.9%, 61.1% vs 83.3%, 74.0% vs 90.0%). The average coronal cage union ratios of the upper and lower endplates in the MCs group were significantly lower than those in the non MCs group (54.3% ± 17.5% vs 75.0% ± 17.2%, P < 0.05; 73.3% ± 12.0% vs 84.9% ± 8.0%, P < 0.05). Similarly, analogous results were obtained by comparing the MCs and non MCs groups' three‐dimensional CT sagittal plane images (62.5% ± 16.5% vs 76.1% ± 12.4%, P < 0.05; 67.0% ± 13.9% vs 79.8% ± 11.5%, P < 0.05).ConclusionShort‐term fusion rates were lower in the MCs group than in the non MCs group. The coronal and sagittal cage union ratio in the MCs group was lower than that in the non MCs group. The fusion performance of n‐HA/PA66 and PEEK cages in the MCs group was comparable.

show abstract

“…Bony endplate (BEP) and cartilaginous endplate (CEP) are the two different layers of EP [ 7 , 8 ]. CEP contains vascular channels when in infancy and early childhood, while the vessels are atretic before adolescence, leaving blood circulation in the BEP only and insufficient nutrition for the disc [ [9] , [10] , [11] , [12] ].…”

Section: Introductionmentioning

confidence: 99%

A lumbar disc degeneration model established through an external compressive device for the study of microcirculation changes in bony endplates

Guo¹,

Yan²,

Xie³

et al. 2023

Heliyon

View full text Add to dashboard Cite

Damage to the human lumbar cartilage endplate and its clinical implications

Cited by 21 publications

References 50 publications

Q‐Dixon and GRAPPATINI T2 Mapping Parameters: A Whole Spinal Assessment of the Relationship Between Osteoporosis and Intervertebral Disc Degeneration

Q‐Dixon and GRAPPATINI T2 Mapping Parameters: A Whole Spinal Assessment of the Relationship Between Osteoporosis and Intervertebral Disc Degeneration

Does Preoperative Modic Changes Influence the Short‐term Fusion Rate of Single Level Transforaminal Lumbar Interbody Fusion?—a Matched‐pair Case Control Study

A lumbar disc degeneration model established through an external compressive device for the study of microcirculation changes in bony endplates

Contact Info

Product

Resources

About