Damage to cell DNA in the bone marrow and testes of mice with experimental trichinosis

Bekish, Vl.Ya.; Дурнев, А. Д.

doi:10.1007/s10517-005-0022-y

Cited by 4 publications

(2 citation statements)

References 8 publications

(8 reference statements)

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“…Личинки анкилостом после контактно-перкутанного заражения человека обусловливают токсико-аллергический дерматит. Кроме того, отечественными учеными получены доказательства высокопатогенного воздействия личинок токсокар на организм человека [1,2].…”

Section: аннотацияunclassified

Helminthozoonosis and Toxoplasmosis in the Ryazan Region

Novak,

Kleimenova

2024

Theory and Practice of Parasitic Disease Control

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Laboratory tests were carried out for toxocariasis, strongyloidiasis, and ancylostomiasis of carnivorous animals and a statistical epidemiological record was made for the prevalence of toxoplasmosis. Fecal samples from dogs were found to have eggs of Strongyloides stercoralisc and Ancylostoma caninum using the flotation method in eight cases out of ten (prevalence = 80%, infection intensitymean = 26 specimens) in the Ryazan Central Park, and in five cases of ten (prevalence = 50%, infection intensitymean = 12 specimens) in the Novopavlovskaya Wood. Using the BermanOrlov method, nematode larval stages were identified in all positive samples: the mean invasion intensity was 38 specimens in one sample in the Central Park, and 26 specimens in the Novopavlovskaya Wood. The method of cultivation in a thermostat found Strongyloides stercoralis and Ancylostoma caninum larvae in quantities of 39 to 45 specimens. In one of the shelters in Ryazan, the diagnosis of toxocariasis was confirmed in 7%, ancylostomiasis in 9%, and strongyloidiasis in 4,5% when examining puppies. A retrospective analysis for toxocariasis in dogs (puppies aged 1.5–3.5 months) showed the following results: 13.2% in 2012, 17.8% in 2015, 15.5% in 2018, 18.1% in 2021, and 14.6% in 2023. According to the Center for Hygiene and Epidemiology of the Ryazan Region, seropositive results for toxoplasmosis were detected in 58 cases with a subclinical, latent course of the disease for 1998 to 2021.

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Section: аннотацияunclassified

Helminthozoonosis and Toxoplasmosis in the Ryazan Region

Novak,

Kleimenova

2024

Theory and Practice of Parasitic Disease Control

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“…Furthermore, the infection pattern of Trichinella spiralis is changing, with the disease re-emerging in some previously disease-free areas [ 25 ]. Studies had reported that the Trichinella spiralis infection increased the number of single-chain breaks and alkaline-labile sites in nuclear DNA, and the count of apoptotic cells in the bone marrow and testes in infected male mice [ 26 ].…”

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confidence: 99%

Infection of Trichinella spiralis Affects the Reproductive Capacity of ICR/CD-1 Male Mice by Reducing the Urine Pheromone Contents and Sperm Quality

Zhang

et al. 2023

IJMS

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Female mice can discriminate the urinary odors of male mice due to their olfactory acuity. Parasitic infection or subclinical infection can decrease the odor attractiveness of male mice and finally lead to aversion or avoidance responses in odor selection for female mice. Trichinella spiralis is a kind of tissue-parasitizing nematode that causes trichinellosis, a zoonotic parasitic disease that spreads throughout the world. However, the reproductive injury caused by Trichinella spiralis infection was not fully revealed. In this study, we explored the effect of Trichinella spiralis infection on the reproductive capacity in ICR/CD-1 male mice. We identified eight volatile compounds in urine by GC-MS analysis, and the results indicated that the contents of dimethyl sulfone, Z-7-tetradecen-1-ol, 6-Hydroxy-6-methyl-3-heptanone and (S)-2-sec-butyl-4,5-dihydrothiazole were significantly downregulated after parasitic infection, which might lead to the reduction of attractiveness of male mice urine to females. On the other hand, parasitic infection decreased sperm quality and downregulated the expression levels of Herc4, Ipo11, and Mrto4, and these genes were strongly related to spermatogenesis. In summary, this study revealed that the reproductive injury caused by Trichinella spiralis infection in ICR/CD-1 male mice could be associated with a decrease in urine pheromone content and sperm quality.

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Effect of TNF Expression by Stromal Cells on Hemopoietic and Stromal Precursor Cells in Long-Term Bone Marrow Cultures Derived from TNF-Deficient Mice

Nifontova

2005

Bull Exp Biol Med

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The effect of TNF expression by wild type stromal sublayer on hemopoiesis was studied in cultures after second inoculation of TNF-deficient bone marrow cells. Long-term maintenance of hemopoiesis was determined solely by the absence of autocrine expression of TNF by hemopoietic cells. The production of hemopoietic precursors of all studied types in TNF-deficient cultures on a wild type sublayer was significantly higher than in cultures without TNF production. Presumably, initial expression of TNF in the sublayer promotes the survival of hemopoietic precursors with high proliferative potential in the culture. It is also obvious that TNF is required for normal functioning of stromal precursor cells.

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Damage to cell DNA in the bone marrow and testes of mice with experimental trichinosis

Cited by 4 publications

References 8 publications

Helminthozoonosis and Toxoplasmosis in the Ryazan Region

Helminthozoonosis and Toxoplasmosis in the Ryazan Region

Infection of Trichinella spiralis Affects the Reproductive Capacity of ICR/CD-1 Male Mice by Reducing the Urine Pheromone Contents and Sperm Quality

Effect of TNF Expression by Stromal Cells on Hemopoietic and Stromal Precursor Cells in Long-Term Bone Marrow Cultures Derived from TNF-Deficient Mice

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