Damage of the pharyngeal mucosa and hyperresponsiveness of airway in sinusitis☆☆☆★★★

Rolla, Giovanni; Colagrande, Paola; Scappaticci, E; Bottomicca, Flavia; Magnano, Mauro; Brussino, Luisa; Dutto, Luca; Bucca, Caterina

doi:10.1016/s0091-6749(97)70194-5

Cited by 48 publications

(29 citation statements)

References 25 publications

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“…RANTES is well known to be increased in serum in acute asthma attacks [46], and anti-RANTES treatment reduces peribronchial inflammation in experimental asthma models [47]. Although midkine is known to be expressed by T cells [48], its contribution to lung disease is unclear.…”

Section: Discussionmentioning

confidence: 99%

T Cell Phenotype in Allergic Asthma and Atopic Dermatitis

Wohlfahrt¹,

Kunzmann²,

Menz³

et al. 2003

Int Arch Allergy Immunol

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Background: T cells are key regulators of immunologic disease parameters. However, their contribution to the process of tissue remodeling is ill defined. In the present study, we investigated gene expression of allergy-characteristic, IL-4-rich T cell cDNAs to monitor expression of genes that might participate in the pathogenesis of allergic diseases. Methods: cDNAs of freshly isolated and restimulated CD4+ T cells from patients with allergic asthma (AA) or atopic dermatitis (AD) and healthy subjects were analyzed on Nylon membrane-based DNA arrays. Three patients were selected for an allergy-characteristic T cell phenotype with high IL-4 expression (AA) or IL-13 expression (AD). Results: Several gene families such as the TGF-β family, chemokines and chemokine receptors were found to be upregulated. Matrix metalloproteinases and their inhibitors were also found to be expressed in an enhanced manner. Furthermore, factors regulating tissue turnover such as fibroblast growth factors and neurotrophic as well as vasoactive factors were found be expressed at a higher level in allergic patient compared to healthy donors. Conclusion: The present study reveals and confirms genes relevant for allergy and highlights an approach to applying a DNA array technique for diagnostic discrimination of allergic diseases.

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Section: Discussionmentioning

confidence: 99%

T Cell Phenotype in Allergic Asthma and Atopic Dermatitis

Wohlfahrt¹,

Kunzmann²,

Menz³

et al. 2003

Int Arch Allergy Immunol

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“…222 This would favor increased access of irritants to submucosal nerve endings, inducing the release of sensory neuropeptides through axon reflexes with activation of a neural arch, resulting in reflex airway constriction.…”

Section: Summary Statementsmentioning

confidence: 99%

The diagnosis and management of sinusitis: A practice parameter update

Slavin

Spector

Bernstein

et al. 2005

Journal of Allergy and Clinical Immunology

328

369

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“…Eosinophilia, extra-and intrathoracic airflow obstruction, epithelial thinning, and sprouting of nerve endings occur together [47,48]. Additional peptides may participate (Table 1).…”

Section: Sinusitismentioning

confidence: 99%

Neurogenic mechanisms in rhinosinusitis

Baraniuk

2001

Curr Allergy Asthma Rep

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Nasal sensory nerve stimulation leads to sensations of pain and congestion and nociceptive nerve axon response-mediated release of substance P that stimulates glandular secretion as an immediate-acting protective mucosal defense. Recruited parasympathetic reflexes cause submucosal gland secretion via muscarinic M3 receptors. Parasympathetic reflexes, sneezing, and other avoidance behaviors rapidly clear the upper airway of offending agents while protecting the lower airways. Dysfunction contributes to allergic, infectious, and other nonallergic rhinitides and possibly sinusitis. Sympathetic arterial vasoconstriction reduces mucosal blood flow, sinusoidal filling, and mucosal thickness, restoring nasal patency. Loss of sympathetic tone may contribute to some chronic, nonallergic rhinopathies.

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Damage of the pharyngeal mucosa and hyperresponsiveness of airway in sinusitis☆☆☆★★★

Cited by 48 publications

References 25 publications

T Cell Phenotype in Allergic Asthma and Atopic Dermatitis

T Cell Phenotype in Allergic Asthma and Atopic Dermatitis

The diagnosis and management of sinusitis: A practice parameter update

Neurogenic mechanisms in rhinosinusitis

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