Damage of the ocular surface from indoor suntanning—Insights from in vivo confocal microscopy

Abstract

To evaluate the ocular surface at the microstructural level of adults who habitually undertake indoorsuntanning utilising in vivo confocal microscopy. Methods: Participants were prospectively recruited and enrolled into either а study group (n = 75) with a history UV indoor tanning, or a control group (n = 75) with no prior history of artificial tanning. The study group participated in voluntary tanning sessions performed with standard equipment and maintained their usual routine for eye protection. Slit lamp biomicroscopy and in vivo confocal microscopy were performed at baseline before undertaking a series of suntanning sessions (10 sessions of 10 min duration over a 15 day period), within three days after the last session, and four weeks after the last session. Control group participants were examined at baseline and 8 weeks later and did not participate in tanning sessions. Results: All participants were female with a mean age of 25 ± 4 years and 24 ± 4 years in the study and control groups, respectively. No clinically significant changes were observed in either group over time using slit lamp biomicroscopy (all p ≥ 0.05), however, statistically significant differences were observed between the study and the control group for all corneal layers imaged using confocal microscopy (all p ≤ 0.03). Characteristic cystic conjunctival lesions with dark centres and bright borders were observed in 95% of the study group before and in 100% after the suntanning sessions. Conclusion: Indoor suntanning resulted in statistically significant microstructural changes in the cornea and the bulbar conjunctiva that are undetectable with slit lamp biomicroscopy.

Pterygium and Ocular Surface Squamous Neoplasia: Optical Biopsy Using a Novel Autofluorescence Multispectral Imaging Technique

“…Pterygium (PTG) and ocular surface squamous neoplasia (OSSN) are two potentially coexistent types of ocular surface tumor, which share similar risk factors, most notably exposure to UV light (Figure 1 a and b) [1,2], damaging the ocular surface [3,4]. While PTG is a benign, proliferative disorder of the ocular surface, OSSN is a neoplastic disease of the conjunctival/corneal epithelia, ranging from mild dysplasia to invasive squamous cell carcinoma (SCC) [5][6][7].…”