Damage of DNA and proteins by major lipid peroxidation products in genome stability

Abstract

"Lipid peroxidation induced damage of DNA and proteins in genome stability" by Winczura et. al.We would like to thank the reviewers for their valuable comments. Enclosed, please find the revised version, which includes answers to all questions raised by the reviewers. We changed the text and table presentation according to reviewers recommendations. All changes are marked in the text in red.Sincerely yours

Evaluation of the in vitro antioxidant properties of a cod (Gadus morhua) protein hydrolysate and peptide fractions

“…The superoxide radical is an in vivo free radical that could promote oxidative reactions because of its ability to reduce transition metals and react with the hydroxyl radical, causing damage to vital cellular components, such as DNA, cell membrane lipids, proteins and enzymes (Winczura, Zdzalik, & Tudek, 2012). Therefore, the body's ability to scavenge superoxide anion radicals is critically important in order to reduce oxidative stress-related destruction of cell biomolecules.…”

Structural and functional characterization of hemp seed (Cannabis sativa L.) protein-derived antioxidant and antihypertensive peptides

“…In biological systems, lipid peroxidation proceeds via a radical-mediated abstraction of hydrogen atoms from methylene carbons in polyunsaturated fatty acids, which initiates a sequenceof reactions that generates aldehydes, ketones and other potentially toxic substances (Winczura, Zdzalik & Tudek, 2012). and 0.60±0.04, respectively.…”

Saccharomyces cerevisiae–like 1 overexpression is frequent in prostate cancer and has markedly different effects in Ets-related gene fusion–positive and fusion-negative cancers

“…Earlier studies have indeed provided evidence for a link between lipid metabolism and maintenance of genomic integrity. Oxidative degradation of lipids (lipid peroxidation) is known to result in formation of reactive oxygen species (ROS) and ROS-associated DNA damage [24]. Accumulation of the lipid peroxidation product malondialdehyde and decreased levels of the ROS-inhibiting lipid-soluble antioxidant vitamins lutein and lycopene have been associated with prostate cancer before [25].…”