Damage-induced basal epithelial cell migration modulates the spatial organization of redox signaling and sensory neuron regeneration
Alexandra M Fister,
Adam Horn,
Michael R Lasarev
et al.
Abstract:Epithelial damage leads to early reactive oxygen species (ROS) signaling, which regulates sensory neuron regeneration and tissue repair. How the initial type of tissue injury influences early damage signaling and regenerative growth of sensory axons remains unclear. Previously we reported that thermal injury triggers distinct early tissue responses in larval zebrafish. Here, we found that thermal but not mechanical injury impairs sensory axon regeneration and function. Real-time imaging revealed an immediate t… Show more
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