Damage effect of chronic intoxication by CCl4 on structural organization of liver microsomes and cytochromes (b)5 and P-450

Cajanus indicus leaf protein: Beneficial role in experimental organ pathophysiology. A review

“…CCl 4 is a potent hepatotoxin and is used to study hepatotoxicity in experimental models [61][62][63]. The activity of the enzymes SOD, catalase, GPx and GST was found to increase in livers of mice treated with CCl 4 whereas they were again back to the normal level in the livers of mice treated with CI-protein.…”

“…These free radicals damage the lipid membranes and other macromolecules present in the cells [63]. As a consequence, organ specific marker enzyme levels increase in blood serum e.g., serum GPT, ALP increase in liver toxicity and creatinine, BUN increase in renal toxicity.…”