A frequency response function change (FRFC) method to detect damage location and extent based on the change in the frequency response functions of a shear building under the effects of ground excitation was proposed in this paper. The damage identification equation was derived from the motion equations of the system before and after the occurrence of the damage. Efforts to make the FRFC method less model‐dependent were made. Intact system matrices, which could be estimated using the measured data without the need for an analytical model, and the frequency response functions were required for the FRFC method. The effects of measurement noise and model parameter error in the FRFC method were studied numerically. The proposed FRFC method was validated by experimental studies of a six‐story steel building structure with single and multiple damage cases. Copyright © 2012 John Wiley & Sons, Ltd.