Damage and functional recovery of the Atlantic cod (Gadus morhua) inner ear hair cells following local injection of gentamicin

Sensory regeneration in the vertebrate inner ear: Differences at the levels of cells and species

“…One unique feature of regeneration in the lateral line is that the supporting cells appear to undergo symmetrical divisions, giving rise to two oppositely-oriented hair cells that reside on opposing sides of the neuromast reversal line (López-Schier and Hudspeth, 2006). Finally, hair cell regeneration in fish is not limited to the lateral line; recovery of functional sensory receptors also occurs after ototoxic injury to the fish inner ear (e.g., Faucher et al, 2009). …”

Regulated Reprogramming in the Regeneration of Sensory Receptor Cells

“…In the vestibular epithelia, regeneration of new hair cells has been reported in the cristae, and the saccule and macula (Warchol, 2010) of all non-mammalian vertebrates that have been studied such as fish (e.g., (Faucher et al, 2009), bullfrogs, newts and birds. In the Bullfrog saccule, many of the regenerated hair cells are newly generated and labeled with BrdU, but at least a fraction of the new hair cells arise from direct transdifferentiation of the support cells; ie.…”

Evoked potentials in the Atlantic cod following putatively innocuous and putatively noxious electrical stimulation: a minimally invasive approach

“…In contrast to previous work in goldfish ( C. auratus ), rainbow trout ( O. mykiss ) (Dunlop and Laming 2005) and the Atlantic salmon ( S. salar ) (Nordgreen et al 2007), this was achieved using a minimally invasive approach to study responses from the entire brain including the brainstem (Faucher et al 2009; Kenyon et al 1998; Slater et al 2010c). Whereas previous studies in other fish species found SEPs with a maximum of two or three response categories and with a maximum latency of about 70 ms, the present approach identified up to 19 (positive and negative) different response peaks with latencies up to 250 ms.…”

“…In the present study, the main aim was to present a novel, minimally invasive approach to assess evoked potentials with putatively nociceptive stimuli in fish, and also to investigate whether we could reproduce findings in freshwater species on a marine teleost fish, the Atlantic cod ( Gadus morhua ). Our minimally invasive method was adapted from studies of auditory evoked potentials in fish (Faucher et al 2009; Kenyon et al 1998) and from studies of evoked potentials with nociception and potential pain in human infants [e.g., (Slater et al 2010a, b, c)]. Briefly, this method involves temporal summation of repetitive stimulus-locked recordings, but rather than using intracranial electrodes in spatially designated brain areas the evoked potentials are recorded from the EEG of the whole brain by using subcutaneous electrodes.…”