Damage accrual in systemic lupus erythematosus in Dominicans in New York City and the Dominican Republic

Geraldino‐Pardilla, Laura; Kapoor, Teja; Canto, Irene del; Perez-Recio, Thania; Then, J.; Tineo, Carmen; Loyo, Esthela; Askanase, Anca

doi:10.1177/0961203318791764

Cited by 1 publication

(3 citation statements)

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“…The reports vary widely in the ethnic composition of the study population, the number of patients and length of follow-up. Some are cross-sectional with SDI measured at a single time point [ 2 , 6 , 12 , 15 , 21 , 25 ] whereas others describe longitudinal SDI data often reported at one-year or five-year time points [ 16 , 18 ]. Very few reports have used Kaplan-Meier analysis to analyse development of damage (as opposed to mortality) over time [ 24 , 26 ].…”

Section: Discussionmentioning

confidence: 99%

“…For other factors, however, findings are inconsistent between different reports. In some cases, this is because the populations studied do not allow assessment of the effects of particular factors; for example, ethnicity in predominantly monoethnic cohorts [ 2 , 6 , 8 , 15 , 16 , 21 , 22 ] or effect of hydroxychloroquine where very few patients are not taking this drug [ 6 , 15 ]. No previous studies have been able to provide Kaplan-Meier curves for development of damage over 30+ years follow-up, as we have done here.…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, Geraldino-Pardilla et al. found considerable differences in disease outcomes and damage between two groups of Dominican patients; one in New York City and the other in the Dominican Republic, suggesting that Dominican ethnicity was not the main factor influencing damage [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

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Damage accrual and mortality over long-term follow-up in 300 patients with systemic lupus erythematosus in a multi-ethnic British cohort

et al. 2019

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Objective Damage in patients with systemic lupus erythematosus is irreversible change in organs due to disease activity, concomitant disease or medication side-effects. It is measured using the Systemic Lupus International Collaborative Clinics Damage Index (SDI) and is associated with increased mortality. Previous reports have suggested associations between damage accrual and various ethnic, disease and treatment factors, but there is a dearth of long-term follow-up data from large multi-ethnic cohorts. We describe a study of damage and mortality in 300 patients from London, UK followed for up to 40 years. Methods We carried out retrospective analysis of medical records and SDI scores of 300 patients followed for up to 40 years (median 13.3 years). Characteristics of the groups who did and did not develop damage and those who died or survived to the end of follow-up were compared using univariable and multivariable analysis. Kaplan-Meier analysis was used to analyse factors affecting mortality and accrual of damage. Results Damage developed in 231/300 (77%) of patients. There was a linear accrual of damage over 40 years follow-up. Factors associated with damage were African/Caribbean ethnicity, renal and cerebral involvement, early use of high-dose corticosteroids or immunosuppressants, anti-RNP and antiphospholipid antibodies. Damage was strongly associated with mortality. Of 87 patients who died, 93% had damage compared with 70% of survivors (P < 0.001). Conclusion Development of damage is strongly associated with increased mortality. We identified groups at increased risk of developing damage, including those treated with high-dose steroids and immunosuppressants within the first two years.

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