Dam methylation influences P. fimbriae expression and binding of fluoroquinolone-resistant UPEC

Abstract

Results: The epidemic-curve showed a propagating pattern, with most cases being detected during or subsequent to ICU admission. Cases had longer mean hospital (27.8 days vs 11.9 days) and ICU stays (31.0 days vs 7.3 days) than controls. The crude in-hospital mortality of cases was significantly higher than controls (OR 13.02; 95% CI: 2.98 -56.76). The final model showed co-morbid disease (Charlson Score) (AOR 1.68; 95% CI: 1.21 -2.33); mechanical ventilation (AOR 1.35; 95% CI: 1.02 -1.16) and receipt of piperacillin-tazobactam (AOR 1.33; 95% CI: 1.11 -1.61) to be significant predictors for invasive disease. Invasive disease was strongly associated with mortality (AOR 9.62; 95% CI: 2.16 -42.93).Conclusion: NDM-1 invasive disease is associated with significant mortality. Underlying co-morbidity, presence of invasive medical devices and exposure to antibiotics are important risk factors for NDM-1 invasive disease.