DALES, Drug Allergy Labels in Elective Surgical patients: a prospective, multicentre cross-sectional study of prevalence, nature and anaesthetists’ approach to management

Thomas, C.; Clark, Sam L.; Fallaha, D.; Wilson, Michelle; Hopkins, Philip M.; Savic, Sinisa; Savic, Louise

doi:10.1016/j.bja.2021.05.026

Cited by 4 publications

(5 citation statements)

References 29 publications

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“…The overall incidence of hypersensitivity reactions was 1:540, which is higher than that in many previous studies 1–3 . The hypersensitivity reactions in our study may have included nonallergic reactions without biochemical indicators such as serum tryptase 4 . In previous studies, clearly diagnosed grade III/IV allergic reactions were more likely to be included; statistical data on grade I/II allergic reactions are lacking.…”

Section: All Patients Positive Group Negative Group χ2 Value P Valuementioning

confidence: 60%

“…[1][2][3] The hypersensitivity reactions in our study may have included nonallergic reactions without biochemical indicators such as serum tryptase. 4 In previous studies, clearly diagnosed grade III/IV allergic reactions were more likely to be included; statistical data on grade I/II allergic reactions are lacking. Limited by the sample size of this study, the grade III/IV allergic reactions with very low incidence may not occur.…”

Section: Ta B L E 1 General Information and Intraoperative Medicationmentioning

confidence: 99%

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Effect of food/air allergies on the incidence of hypersensitivity reactions in minors under general anesthesia

Chen

Shen

2022

Pediatric Anesthesia

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Section: All Patients Positive Group Negative Group χ2 Value P Valuementioning

confidence: 60%

Section: Ta B L E 1 General Information and Intraoperative Medicationmentioning

confidence: 99%

Effect of food/air allergies on the incidence of hypersensitivity reactions in minors under general anesthesia

Chen

Shen

2022

Pediatric Anesthesia

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“…This belief is cited as a major reason for anaesthetists not being willing to give penicillin to patients delabelled by direct oral challenge. 6 , 14 In our study, knowledge was not a barrier, i.e. anaesthetists in our survey believed they have the knowledge required to be able to give penicillin to a patient delabelled by direct oral challenge.…”

Section: Discussionmentioning

confidence: 71%

Eliciting the barriers and enablers towards anaesthetists giving penicillin-based antibiotic prophylaxis to low-risk patients who have had their penicillin allergy label removed as part of a preoperative delabelling process

Roberts,

Fontaine,

Sandoe

et al. 2024

JAC-Antimicrobial Resistance

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Background Some penicillin allergy labels can be removed by non-allergy specialists by direct oral challenge, but there is reluctance amongst anaesthetists to give penicillin to these patients. We aimed to assess anaesthetist beliefs about giving penicillin to patients delabelled by direct oral challenge. Methods A survey, developed using the Theoretical Domains Framework, was circulated to anaesthetists within a regional research network in England. Domains were rated using 5-point Likert scales. Overall and group medians were used to dichotomize domains rated by group into ‘relatively important/unimportant’ and ‘relative enabler/barrier’. Results We received 257 responses from six hospitals (response rate 49.7%). Seven domains were rated as important for all stakeholder groups and hospitals: Knowledge, Skills, Belief in Capabilities, Belief in Consequences, Memory/Attention/Decisions, Environmental Context and Resources, and Emotions. Social and Professional Role was also important to all respondents except those in one hospital. Intentions and Optimism were rated as important for some groups/hospitals and unimportant for others. All four other domains were rated as unimportant for all groups/hospitals. All domains rated as important were enablers for all groups/hospitals, with the exception of Memory/Attention/Decisions and Emotions, which were rated as discordant barriers/enablers between groups. This means they were acting as a barrier for some staff groups/hospitals and an enabler for others. Barrier domains (Reinforcement, Goals, Social Influences, Behavioural Regulation) were all rated unimportant. Conclusions Behavioural influences on giving penicillin prophylaxis to a delabelled patient are complex and nuanced. These findings could inform targeted interventions, both across and within hospitals and staff groups.

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“…Informal clinical research experience can be gained throughout training by participating in collaboratives such as the Sprint National Anaesthesia projects 6 , 7 or the Research and Audit Federation of Trainees. 8 , 9 …”

Section: Academic Anaesthesiology Training and Research Funding Aroun...mentioning

confidence: 99%

“… 42 , 43 These factors have led to clinical trainees seeking to gain the research exposure necessary to meet the requirements of their training programme working within a more collaborative research model of recruiting to large studies, or those run by trainee research networks. 9 Although these provide an element of research exposure, they generally do not allow individuals to get any formal or in-depth training in research.…”

Section: Current Challenges Solutions and Unique Opportunitiesmentioning

confidence: 99%

Academic anaesthesiology: a global perspective on training, support, and future development of early career researchers

Stundner,

Adams,

Fronczek

et al. 2023

British Journal of Anaesthesia

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DALES, Drug Allergy Labels in Elective Surgical patients: a prospective, multicentre cross-sectional study of prevalence, nature and anaesthetists’ approach to management

Cited by 4 publications

References 29 publications

Effect of food/air allergies on the incidence of hypersensitivity reactions in minors under general anesthesia

Effect of food/air allergies on the incidence of hypersensitivity reactions in minors under general anesthesia

Eliciting the barriers and enablers towards anaesthetists giving penicillin-based antibiotic prophylaxis to low-risk patients who have had their penicillin allergy label removed as part of a preoperative delabelling process

Academic anaesthesiology: a global perspective on training, support, and future development of early career researchers

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