Dairy protein and leucine alter GLP-1 release and mRNA of genes involved in intestinal lipid metabolism in vitro

Chen, Qixuan; Reimer, Raylene A.

doi:10.1016/j.nut.2008.08.012

Cited by 142 publications

(112 citation statements)

References 49 publications

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“…We showed significantly greater GLP-1 and GIP responses in the ORAL BCAA test, and there was no significant incremental change observed in the IV and PLACEBO test. We showed both GLP-1 and GIP responses after oral BCAA, which is in contrast to previously published data [13,16]. Whether this is due to a higher dose used in the current study or a special incretin-stimulating effect of BCAA remains to be established.…”

Section: Discussioncontrasting

confidence: 99%

“…It has been shown that intra-duodenal [12] as well as oral administration [13] of an AA mixture elicit a greater insulin response compared with IV administration. Increase in incretin levels has already been shown after oral whey administration and AA mixtures [3,13,14,15] and in vitro GLP-1 response has been demonstrated in an intestinal cell line after incubation with BCAA [16]. It could be therefore hypothesized that incretin effect of oral BCAA contributes significantly to insulinotropic properties of whey and AA mixtures.…”

Section: Introductionmentioning

confidence: 99%

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Increased Incretin But Not Insulin Response after Oral versus Intravenous Branched Chain Amino Acids

Gojda¹,

Straková²,

Plíhalová³

et al. 2017

Ann Nutr Metab

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Background/Aims: Branched chain amino acids (BCAAs) are known to exert an insulinotropic effect. Whether this effect is mediated by incretins (glucagon like peptide 1 [GLP-1] or glucose-dependent insulinotropic peptide [GIP]) is not known. The aim of this study was to show whether an equivalent dose of BCAA elicits a greater insulin and incretin response when administered orally than intravenously (IV). Methods: Eighteen healthy, male subjects participated in 3 tests: IV application of BCAA solution, oral ingestion of BCAA and placebo in an equivalent dose (30.7 ± 1.1 g). Glucose, insulin, C-peptide, glucagon, GLP-1, GIP, valine, leucine and isoleucine concentrations were measured. Results: Rise in serum BCAA was achieved in both BCAA tests, with incremental areas under the curve (iAUC) being 2.1 times greater for IV BCAA compared with those of the oral BCAA test (p < 0.0001). Oral and IV BCAA induced comparable insulin response greater than placebo (240 min insulin iAUC: oral 3,411 ± 577 vs. IV 2,361 ± 384 vs. placebo 961.2 ± 175 pmol/L, p = 0.0006). Oral BCAA induced higher GLP-1 (p < 0.0001) and GIP response (p < 0.0001) compared with the IV or placebo. Glucose levels declined significantly (p < 0.001) in the same pattern during both BCAA tests with no change in the placebo group. Conclusions: An equivalent dose of BCAA elicited a comparable insulin and greater incretin response when administered orally and not when administered through IV. We conclude that insulinotropic effects of BCAA are partially incretin dependent.

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Section: Discussioncontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Increased Incretin But Not Insulin Response after Oral versus Intravenous Branched Chain Amino Acids

Gojda¹,

Straková²,

Plíhalová³

et al. 2017

Ann Nutr Metab

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“…Peynir altı suyu proteinleri, yeni protein sentezinde önem taşıyan zincir aminoasitlerin %26'sına kadar sağlamakta-dır. 10,20 …”

Section: Egzersi̇zunclassified

“…8,9 Lözin, m-RNA fonksiyonunu kontrol eden proteinlerin dönüşümlü fosforilizasyonunu kolaylaştırmakta ve böylece kas protein sentezini artırmaktadır. 10 İskemik atak geçiren yaşlı hastalarda peynir altı suyu proteini ihtiva eden enteral formülasyonların inflamasyonu azalttığı ve antioksidan savunmayı artırdığı rapor edilmiştir.…”

unclassified

Whey Protein: A New Supportive and Regenerative Therapy Chance Ignored in Veterinary Medicine: Review

Dalğın¹,

Yücel²

2016

Turkiye Klinikleri J Vet Sci

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Ö ÖZ ZE ET T Peynir altı suyu, daha önceleri, peynir yapımının bir atık ürünü olarak ele alınmakta idi, fakat son yıllarda bileşimi ortaya konularak, içeriği oluşturan aminoasit, immünglobulin, büyüme faktörleri gibi maddelerin antimikrobiyal, antiviral, antifungal, epitelizan, immün stimülan, rejeneratif gibi birçok terapötik etkileri tanımlanmıştır. Beşerî hekimlikte peynir altı suyu immün stimülasyon amacıyla özellikle yaş-lılarda iskemik atakta, "human immunodeficiency virus" (HIV) enfeksiyonunda, pek çok hastalıkta antimikrobiyal amaçlı (Escherichia coli, Salmonella typhimurium, Shigella dysenteriae, Listeria monocytogenes, Bacillus stearothermophilus, Bacillus subtilis, Micrococcus luteus, Pseudomonas aeruginosa, Listeria monocytogenes, Candida albicans ve Helicobacter pylori), egzersiz ve sporcularda kas yapımında, gastrointestinal sistem hastalıklarında, kanser hastalarında, osteoporözde, ağız ve diş sağlığında, depresyon, stres ve kozmetik sektörü gibi pek çok alanda kullanılmaktadır. Oysa güncel literatür tarandığında, bu ürünün maalesef veteriner hekimlik alanında çok fazla araştırılmamış, özellikle de rutin kullanıma girmekten çok uzak olduğu görülmektedir. Doğal ve maliyeti düşük olan peynir altı suyunun, ister toz hâ-linde, ister taze sıvı hâlde; barsak hastalıkları, köpeklerin parvoviral enteritisi, yangısal barsak hastalığı, yenidoğan ve gelişme geriliği gösteren yavrular, viral, bakteriyel, paraziter hastalıklar, geriatri, kanser hastalığı gibi durumlarda destek ve rejeneratif tedavi yönünden değerlendirilmesi ile terapi başarısına önemli ölçüde katkı sağlayacağı kanaatindeyiz. Bu çalışmada, peynir altı suyunun içeriği, beşerî ve veteriner hekimlik sahasında kullanım alanları özetlenmiştir.A An na ah h t ta ar r K Ke e l li i m me e l le er r: : Vey protein; veterinerlik bilimi; tedavi A AB BS S T TR RA AC CT T Whey was a waste product of cheese manufacturing previously, but in the last decades with the identification of its content, it is used in many areas of human medicine as a supportive element because of the antimicrobial, antiviral, antifungal, epithelialing, immune stimulant, regeneratif effects due to its amino acid, immune globuline, growth factors etc. components. Major areas whey proteins are used in human medicine are immune stimulation, ischemic attack especially in elderly, , human immunodeficiency virus (HIV) infection, in many disorders as antimicrobials (Escherichia coli, Salmonella typhimurium, Shigella dysenteriae, Listeria monocytogenes, Bacillus stearothermophilus, Bacillus subtilis, Micrococcus luteus, Pseudomonas aeruginosa, Listeria monocytogenes, Candida albicans and Helicobacter pylori), exercise and by sportsmen for muscle protein synthesis, gastrointestinal system disorders, neoplastic disorders, osteoporesis, oral and dental health, depression and stress and cozmetic areas. Unfortunately, current literature shows that this product has not been invesitigated and very far from clinical application in veterinary medicine. The authors opinion is that, this economically ...

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“…A number of other dietary-based GLP-1 secretagogues have been reported [4,13,17,22,26] but pharmacologically there is a focus on targeting several intestinal GPCRs believed to be important in modulating gut hormone secretion. These include the bile acid receptor TGR5 [25] and fat-sensing receptors GPR40, GPR119, and GPR120 [38] all of which are present on the surface of enteroendocrine cells.…”

Section: Introductionmentioning

confidence: 99%

Naturally-occurring TGR5 agonists modulating glucagon-like peptide-1 biosynthesis and secretion

et al. 2016

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show abstract

Dairy protein and leucine alter GLP-1 release and mRNA of genes involved in intestinal lipid metabolism in vitro

Cited by 142 publications

References 49 publications

Increased Incretin But Not Insulin Response after Oral versus Intravenous Branched Chain Amino Acids

Increased Incretin But Not Insulin Response after Oral versus Intravenous Branched Chain Amino Acids

Whey Protein: A New Supportive and Regenerative Therapy Chance Ignored in Veterinary Medicine: Review

Naturally-occurring TGR5 agonists modulating glucagon-like peptide-1 biosynthesis and secretion

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