Dairy products and metabolic syndrome among Iranian adult population: Isfahan Healthy Heart Program

Mohammadifard, Noushin; Akhavan-Tabib, Afshan; Sajjadi, Firouzeh; Alikhasi, Hassan; Taheri, Marzieh; Khani, Azam; Karimi, Simin

doi:10.1016/j.idairyj.2020.104667

Cited by 2 publications

(3 citation statements)

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“…However, a study in Iran showed no significant association between dairy consumption and body weight (45). It should be noted that total dairy consumption more than twice a week could reduce MetS and its component (46). The differences in the result of studies may be due to differences in the dietary pattern of the study population.…”

Section: Discussionmentioning

confidence: 99%

Association of a genetic variant in the AKT gene locus and cardiovascular risk factors

Kermanshahi

Ghazizadeh

Hussein

et al. 2020

Cell Mol Biol (Noisy-le-grand)

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Cardiovascular disease (CVDs) is the leading cause of morbidity and death worldwide. Most genetic variants could be identified by several genome-wide-association-studies (GWAS), including within genes encoding proteins involved in the AKT/PI3K pathways that are related with an increased risk of metabolic syndrome and CVDs. Therefore, due to the importance of genetic variants in the prognosis of diseases, we examined the genetic polymorphism of AKT-rs1130233 located on chromosome 14 with cardiovascular risk factors. In this cross-sectional study, 721 subjects recruited from the Mashhad-Stroke and Heart-Atherosclerotic-Disorders (MASHAD) cohort study. The participants including 257 subjects with metabolic syndrome, 144 subjects with cardiovascular disease and 320 subjects as a control group. Anthropometric, biochemical and demographic information measures were prepared. Dietary assessment was managed by 24h dietary recall. DNA extraction and genotyping were carried out by using the TaqMan real-time-PCR based method. The association of AKT rs1130233 locus with dietary intakes, metabolic syndrome and cardiovascular risk factors were assessed. Data were analyzed by using SPSS 21 software. Frequencies of genotypes AA, AG and GG of the AKT rs1130233 polymorphism were 12.6%, 44.5% and 42.9% in subjects with metabolic syndrome and 9.7%, 39.6% and 50.7% in subjects with cardiovascular disease, respectively. The frequency of allele A and G in cardiovascular disease and metabolic syndrome population were 29.5%, 70.5% and 34.8%, 65.2%, respectively. We have found no significant association between the AKT rs1130233 polymorphism with cardiovascular risk factors and metabolic syndrome. The results of dietary intake showed that the levels of phosphorus intake (p=0.008), calcium intake (p=0.007) and iodine intake (p=0.04) were different in subjects with and without metabolic syndrome. And also, energy intake was significantly different in subjects with cardiovascular disease (p=0.01) compared to the control group. Our findings suggest that AKT rs1130233 was not associated with the risk of metabolic syndrome and cardiovascular disease in the Iranian population. More studies are needed to validate our results. We did functional analysis, due to certify our investigation about value of this genetic biomarker for CVD risk.

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Section: Discussionmentioning

confidence: 99%

Association of a genetic variant in the AKT gene locus and cardiovascular risk factors

Kermanshahi

Ghazizadeh

Hussein

et al. 2020

Cell Mol Biol (Noisy-le-grand)

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“…A total of 35 studies including 12 cohort studies [ 22 , 23 , 24 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 ] with 40,943 subjects and 9436 cases and 25 cross-sectional [ 17 , 18 , 19 , 20 , 21 , 25 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 ] studies with 362,196 subjects were included in meta-analyses of the highest versus the lowest dairy product consumption and risk of MetS ( Figure 1 ). Table 3 presents the characteristics of studies included in the meta-analysis.…”

Section: Resultsmentioning

confidence: 99%

“…Thus, we included both cohort and cross-sectional studies, and conducted subgroup analyses for total dairy products, milk, yogurt, and cheese consumption. Moreover, we included more recent two cohort studies (three articles) [ 23 , 24 , 44 ] and 11 cross-sectional studies (11 articles and the current results of the KNHANES data) [ 21 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 ] including the first large multinational studies [ 61 ]. In the present meta-analysis, we not only performed stratified analyzes by geographic region and adjustment for confounders like the previous meta-analyses [ 7 , 8 ] but also performed analyses stratified by sex and MetS criteria.…”

Section: Discussionmentioning

confidence: 99%

Dairy Consumption and Risk of Metabolic Syndrome: Results from Korean Population and Meta-Analysis

Jin

2021

Nutrients

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Dairy consumption has been associated with decreased risk of metabolic syndrome (MetS) in previous studies, but the association may be different according to each type of dairy products and its subgroups. Thus, we conducted an updated meta-analysis of observational studies to examine the association between various dairy products and risk of MetS. The PubMed and Web of Science databases were searched for eligible studies published up to February 2021. In addition, we included unpublished results from Korea National Health and Nutrition Examination Survey, 2013–2018, including 23,319 Korean adults and the elderly. A total of 35 studies (12 cohort studies and 25 cross-sectional studies) with 398,877 subjects were included in the meta-analysis. The pooled relative risks (RR) of MetS for the highest versus lowest categories of dairy consumption was 0.80 [95% confidence interval (CI): 0.72–0.88]. For the type of dairy products, there were also significant inverse associations with milk (RR: 0.83; 95% CI: 0.78–0.89) and yogurt consumption (RR: 0.89; 95% CI: 0.83–0.95). For cheese consumption, however, no significant association was found (RR: 0.98; 95% CI: 0.86–1.11). Our findings suggest that milk and yogurt consumption is inversely associated with the risk of MetS, but not cheese consumption.

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Dairy products and metabolic syndrome among Iranian adult population: Isfahan Healthy Heart Program

Cited by 2 publications

References 50 publications

Association of a genetic variant in the AKT gene locus and cardiovascular risk factors

Association of a genetic variant in the AKT gene locus and cardiovascular risk factors

Dairy Consumption and Risk of Metabolic Syndrome: Results from Korean Population and Meta-Analysis

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